Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P15088 (mast cell)
 14,925 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fifteen extraction sockets packed with a new drug combination which includes a local anaesthetic (cincain chloride), a local antiseptic (tri-iodomethane) and two drugs with a potent antifibrinolytic activity (tranexamic acid and propyl-hydroxy-benzoic acid) in an absorbable gelatin sponge (Gelfoam) as a vehicle, were histologically assessed with special reference to the parameters related to wound healing. As a control, the same number of sockets were allowed to heal spontaneously and similarly assessed. Healing of the extraction wounds seemed to follow the normal sequence in both series, and no histological signs suggestive of a delay in the healing process could be found in any of the sockets studied. Also the mast cell count previously considered to be of importance in the connective tissue repair was found to be unaffected by the test substance. These results, together with the previously presented data on the clinical efficacy of the drug combination studied, suggest that a larger clinical study should be carried out to assess its value as a preventive measure against the development of the post-extraction symptoms, including dry socket.
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PMID:The effects on extraction wound healing of a new drug combination introduced for use in the prevention of post-extraction complications. A preliminary report. 693 42

In this experimental study performed on the rat middle ear either the Eustachian tube or the tympanic isthmus was blocked via the tympanic bulla with a polyethylene plug or a piece of Gelfoam, respectively. Effusion material was immediately observed in the attic space and subsequently the pars flaccida was drawn in a medial direction to form a retraction pocket. The initial changes in the pars flaccida structure were a degranulation of the mast cells and concomitantly metaplasia of the mucosal epithelium into cells displaying numerous osmiophilic inclusions, vacuoles and multivesicular bodies. It cannot be excluded that the initial cause of the effusion production is the histamine released from mast cell granules.
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PMID:Structure of the pars flaccida after occlusion of the Eustachian tube or blockade of the tympanic isthmus. 711 52