Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P15088 (
mast cell
)
14,925
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The effects of
IPD
-1151T (suplatast tosilate), a novel anti-allergic drug, on murine
mast cell
induction were examined by the in vitro cell culture technique. Spleen cells from BALB/c mice suspended in RPMI-1640 medium containing interleukin 3 were cultured in the presence or absence of
IPD
-1151T. Half the volume of the medium was changed every 4 days. Mast cell numbers increased as the culture time went on and reached a peak on the 16th day, when spleen cells were cultured without
IPD
-1151T. However, induction of mast cells from spleen cell cultures was inhibited by
IPD
-1151T in a dose dependent fashion. These results strongly suggest that
IPD
-1151T is a very useful agent for therapy in allergic diseases.
...
PMID:[Inhibitory effect of IPD-1151T (suplatast tosilate) on mast cell induction from normal mouse spleen cells]. 133 62
The influence of
IPD
-1151T (suplatast-tosilate) on murine
mast cell
induction was examined by in vitro cell culture. Splenocytes from BALB/c mice suspended in RPMI-1640 medium supplemented with interleukin-3 were cultured in the presence or absence of
IPD
-1151T. Half of the total volume of the medium was changed every 4-5 days. The number of mast cells increased with culture time and reached a peak on the 16th day when the cells were cultured without
IPD
-1151T. However, the growth of mast cells from the splenocyte culture was dose dependently inhibited by
IPD
-1151T. Furthermore,
IPD
-1151T inhibited the proliferation of
mast cell
progenitor cells, IC-2, but not that of splenocytes or mature mast cells.
...
PMID:Suppressive effects of IPD-1151T (suplatast-tosilate) on induction of mast cells from normal mouse splenocytes. 795 88
