Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P15088 (mast cell)
 14,925 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 4-year-old female patient who developed a skin eruption similar to pityriasis rosea after treatment with ketotifen (Zaditen) is presented. The relationship between ketotifen and the eruption has been based on circumstantial evidence and confirmed by the positive results of the MIF test and the rat mast cell degranulation test.
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PMID:Pityriasis rosea and ketotifen. 293 81

Zaditen has a partial blocking effect in exercise-induced asthma, but the mechanism of this effect is unknown. In our study we investigated the effect of Zaditen on one of the mediators released by mast cells. We measured the serum neutrophil chemotactic activity - by using a modified Boyden chamber assay - after 2 week's treatment with Zaditen or placebo. The airway parameters (SGaw) were recorded with a wholebody plethysmograph. Our studies on 10 patients show that Zaditen has a protective effect on the release of the neutrophil chemotactic factor during an exercise challenge test. A direct effect of Zaditen on the mast cell degranulation process is postulated.
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PMID:Effect of Zaditen on serum neutrophil chemotactic activity in exercise-induced asthma. 397 90

Ketotifen fumarate, formulated for the treatment of allergic conjunctivitis, is a histamine H1-receptor antagonist, mast cell stabilizer, and eosinophil inhibitor (decreases chemotaxis and activation of eosinophils). In this study, healthy volunteers 3 years of age or older received ketotifen fumarate .025% ophthalmic solution (n = 330) or placebo (n = 165) four times daily for 6 weeks. Ketotifen was safe and well tolerated in the adult and pediatric populations, with an incidence of ocular adverse events of 18.2%, compared with 15.2% with placebo. No ocular rebound vasodilation or itching was observed within 48 hours after treatment. Ketotifen has a favorable safety and tolerability profile, which may have a positive impact on compliance, an important aspect of effective symptomatic control of allergic conjunctivitis.
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PMID:Ocular tolerability and safety of ketotifen fumarate ophthalmic solution. 1243 Oct 41