Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P15088 (mast cell)
 14,925 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Methotrexate(MTX) and the methotrexate-alpha-peptides(MTX-alpha-phenylalanine and MTX-alpha-arginine i.e. MTX-alpha-Phe and MTX-alpha-Arg) were prepared with the technique of solid-phase peptide synthesis. Its purity was verified as a single peak by HPLC and its molecular weight was measured by mass spectrometry. MTX-alpha-Phe could be hydrolyzed to MTX by carboxypeptidase A. The cytotoxic effect of released MTX was found to be 100 times stronger than that of the peptide in vitro. It is suggested that MTX-alpha-Phe is a satisfactory prodrug in the treatment of cancer.
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PMID:[The solid-phase synthesis of methotrexate-alpha-peptides]. 1124 92