Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P15088 (mast cell)
 14,925 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of collagen degradation products by bacterial (BCDP) and synovial fluid collagenase (SCDP) on histamine release from peritoneal mast cells of rat was estimated. Some BCDP as well as SCDP released 60-80% of mast cell histamine. In BCDP fraction the most active were BCDP II (m.wt. 13 kD) and BCDP III (m.wt. 6 kD). The last contained the highest percentage of hydroxyproline. As compared with bradykinin, BCDP III was about 50 fold more active as histamine releaser.
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PMID:Collagen-derived peptides release mast cell histamine. 242 89