Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P15088 (mast cell)
 14,925 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Seven synthetic peptides corresponding to amino acid sequences located within various surface regions of the CH3 and CH4 domains of rat IgE were tested for their capacity to compete with intact rat IgE for binding sites on mast cells. Peptides representing rat IgE sequences 414-428 (P129), 459-472 (P124), 491-503 (P128) and 542-557 (P123) inhibited the binding of 125I-labeled rat IgE to mast cells by between 25-50% at concentrations between 10(-5)-10(-4) M. Three other rat IgE sequences, 378-396 (P130), 522-535 (P122) and 560-571 (P131), and three non-IgE peptides demonstrated no inhibitory activity. On a molar basis, the most active peptide, P129, was approximately 1000-times less active than native rat IgE. Furthermore, extensive washing of cells incubated with this peptide did not reduce its ability to inhibit the subsequent binding of 125I-labeled rat IgE. These results suggest that residues within sequences 414-428, 459-473, 491-503 and 542-557 may contribute towards the mast cell receptor binding site on rat IgE.
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PMID:Inhibition of binding of rat IgE to rat mast cells by synthetic IgE peptides. 295 12

Receptors that display negative signalling functions on lymphocytes and other cells of the reticuloendothelial system now number about 30. These negative receptors are transmembrane glycoproteins activated by phosphorylation of a tyrosine residue in immunoreceptor tyrosine-based inhibitory motifs that bind various phosphatases to induce dominant negative signals. Since these receptors are armed by the action of activating receptors and inhibit signalling by activating receptors, we have termed them coinhibitory receptors and the negative outcome is coinhibition. Coinhibitory receptors and some inhibitory mediators include FcgammaRIIB, CTLA-4, CD5, CD22, p58/70/140 KIR, gp49B1/gp91, PIRB1-5, LAIR-1, NKB1, Ly49 A/C/E/F/G, NKG2-A/B APC-R, CD66, CD72, PD-1, SHPS-1, SIRP-alpha1, ILT1-5, MIR7, 10, hMIR(HM18), hMIR(HM9), LIR1-3,5,8, Fas (CD95), TGFbeta-R, TNF-R1, IFNgamma-R (alpha and beta chains), mast cell function Ag, H2-M, HLA-DM, CD1, CD1-d, CD46, c-cbl, Pyk2/FADK2, P130 Ca rel prot, PGDF-R, LIF, LIF-R, CIS, SOCS13 and 5, and others are being defined regularly. This long list suggests that coinhibitors are needed not only for self-nonself discrimination, but also for control of ongoing responses to foreign antigens so that infectious agents are ideally dealt with by an appropriate level of immune responses to nonself and an appropriate amount of immunopathology and sickness behaviour.
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PMID:Why so many coinhibitory receptors? 1040 45