Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P15088 (mast cell)
 14,925 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It is known that cancer is not a single transformational event. It is rather a multistage process involving complex interactions with the surrounding cellular microenvironment. Mast cells accumulate at sites of tumor growth in response to numerous chemoattractants. Our aim was to investigate the relationship between mast cell density (MCD) and myometrial invasion in endometrial carcinomas. Immunohistochemistry was performed on 35 unselected consecutive hysterectomy specimens from patients with endometrial adenocarcinoma. C-kit-positive mast cell assessment was performed in the myometrium adjacent to tumor tissue. A mean number of <or=15 mast cells per high power field (HPF) were regarded as low mast cell density (L-MCD), and a count of >or=16 mast cells was regarded as high mast cell density (H-MCD). A significant correlation (p=0.018, Pearson Chi-Square test) between H-MCD and the presence of myometrial invasion was demonstrated in endometrial carcinomas. H-MCD was found in 54% of all cases, and 94% of H-MCD cases had myometrial invasion, suggesting a role of mast cells or an interaction with tumor. Therapeutic modalities orientated to these cells or their microenvironment as a new target for adjuvant treatment might determine the prognosis in endometrial carcinomas.
 ...
PMID:The association of mast cell density with myometrial invasion in endometrial carcinoma: a preliminary report. 2018 90

In this study, we correlated the number of tryptase-reactive mast cells with the number of CD8-positive T cells in human endometrial adenocarcinoma biopsy specimens by means of immunohistochemical techniques. Results have shown that CD8-positive T cell counts correlate to tryptase-positive mast cell counts and that these parameters increase in accordance with the tumor progression of human endometrial carcinoma. These data suggest that inhibition of inflammation or manipulation of inflammatory resolution pathways may be a new therapeutic approach for the treatment of endometrial adenocarcinoma.
 ...
PMID:Tryptase-positive mast cells and CD8-positive T cells in human endometrial cancer. 2170 49