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Target Concepts:
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Query: UNIPROT:P15088 (
mast cell
)
14,925
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A murine model of chronic graft-versus-host disease (GVHD) was induced across minor histocompatibility barriers. This was done by injecting B10.D2 (H-2d) spleen cells into irradiated BALB/c (H-2d) mice.
Chronic GVHD
in this model includes features common to human idiopathic scleroderma, such as dermal fibrosis, loss of dermal fat and appendages, and a mononuclear cell filtrate. Serial skin biopsies showed a progressive loss of stainable mast cells in GVHD but not in irradiated controls. Mast cell depletion was noted as well in the tongue and kidney capsule of GVHD mice. Mast cell depletion was noted as early as 11 days after GVHD induction and persisted for at least 56 days. A hypothesis is put forth linking the T-cell activation of GVHD,
mast cell
degranulation, and increased fibrosis. The pertinence of this hypothesis to idiopathic scleroderma is pointed out.
...
PMID:Mast cell depletion in murine chronic graft-versus-host disease. 398 Oct 34
Allogeneic hematopoietic stem cell transplant (allo-HSCT) is often used to treat acute leukemia or defects of hematopoiesis. Its widespread use is hampered by graft-vs.-host disease (GVHD), which has high morbidity and mortality in both acute and chronic subtypes.
Chronic GVHD
(cGVHD) occurs most frequently in skin and often is characterized by pathogenic fibrosis. Mast cells (MCs) are known to be involved in the pathogenesis of other fibrotic diseases. In a murine model of cGVHD after allo-HSCT, C57BL/6J recipients of allogeneic LP/J donor cells develop sclerodermatous dermal cGVHD which is significantly decreased in
mast cell
-deficient B6.Cg-Kit
W-sh/
HNihrJaeBsmGlliJ recipients. The presence of MCs is associated with fibrosis, chemokine production, and recruitment of GVHD effector cells to the skin. Chemokine production by MCs is blocked by drugs used to treat cGVHD. The importance of MCs in skin cGVHD is mirrored by increased MCs in the skin of patients with dermal cGVHD. We show for the first time a role for MCs in skin cGVHD that may be targetable for preventive and therapeutic intervention in this disease.
...
PMID:Mast Cells Are Mediators of Fibrosis and Effector Cell Recruitment in Dermal Chronic Graft-vs.-Host Disease. 3168 36
