Gene/Protein
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Enzyme
Compound
Pivot Concepts:
Gene/Protein
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Target Concepts:
Gene/Protein
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Query: UNIPROT:P15088 (
mast cell
)
14,925
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The topographic distribution, population density, and ultrastructural features of mast cells were studied in six cases of cerebellar capillary
hemangioblastoma
. The vascular area of tumor tissue contained large numbers of mast cells (6.3 cells/high power field, X 400) in comparison with hyalinized area (0.3 cell) and adjacent cerebellar tissue (less than 0.1 cell). Close association of mast cells with endothelial cells and stromal cells was found. The morphology of
mast cell
granules and their degranulation through dissolution of granule contents and exocytosis were illustrated. The findings suggest that an increased number of mast cells may represent one of the characteristic histological features of capillary
hemangioblastoma
, and continuous degranulation of
mast cell
granules with release of heparin may play an important pathophysiologic role in the vascular proliferation and expansion of the tumor.
...
PMID:Ultrastructure of cerebellar capillary hemangioblastoma. II. Mast cells and angiogenesis. 654 93
