Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P15088 (mast cell)
 14,925 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mast cells reaction in the wall of the normal fallopian tubes has been studied morphometrically in 48 women subjected to the operation for a uterine myoma and ovarian retention cyst. It has been stated that volume and degree of the mast cell degranulation depends on the menstrual cycle phase, age and part of the fallopian tube. The changes of the mast cells reaction correlate with the capillary diameters in the ampulla and the isthmus of the oviduct. Labrocytes participate in regulation of the microcirculatory blood stream of the fallopian tubes.
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PMID:[Cyclic changes in mast cell response and capillaries in the wall of the Fallopian tubes of women]. 743 60

Uterine leiomyoma is a mesenchymal tumor composed of smooth muscle cells with fibrous tissues and many mast cells. Tranilast is known to suppress fibrosis or to work as a mast cell stabilizer and is reported to inhibit proliferation of vascular smooth muscle cells. In this study, we examined the effects of tranilast on cultured human leiomyoma cells in vitro to evaluate whether this agent has the potential to inhibit the growth of uterine leiomyomas. Tranilast inhibited the proliferation of cultured leiomyoma cells in a dose-dependent manner without any cytotoxic effect or induction of apoptosis. In association with the inhibitory effect, tranilast induced the cyclin-dependent kinase (CDK) inhibitor p21(waf1) and tumor suppressor gene p53 and decreased CDK2 activity. These results suggest that tranilast arrests the proliferation of uterine leiomyoma cells at the G0/G1 phase, through the suppression of CDK2 activity via an induction of p21(waf1) and p53. Tranilast was concluded to be a potent agent to inhibit proliferative activity of uterine leiomyoma cells.
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PMID:Tranilast inhibits the proliferation of uterine leiomyoma cells in vitro through G1 arrest associated with the induction of p21(waf1) and p53. 1246 60