Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P15088 (
mast cell
)
14,925
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-
HHT
) is a 17-carbon hydroxy fatty acid that is biosynthesized either by enzymatic pathways, like thromboxane synthase (TXAS) and cytochrome P450 or a non-enzymatic pathway. TXAS catalyzes the isomerization reaction from PGH
2
to 12-
HHT
, malondialdehyde, and TXA
2
at a ratio of 1:1:1. Furthermore, 12-
HHT
has been considered as a mere byproduct of TXA
2
biosynthesis, and its biological function has long been uncertain. BLT2 was initially identified as a low-affinity leukotriene B
4
(LTB
4
) receptor, which is also activated by various hydroxy-eicosatetraenoic acids (HETEs), suggesting that BLT2 may be activated by other endogenous ligands apart from LTB
4
and HETEs. By unbiased ligand screening using crude lipids from rat organs, 12-
HHT
has been identified as an endogenous agonist for BLT2. The 12-
HHT
-BLT2 axis induces
mast cell
migration and contributes to allergic inflammation. BLT2 is also expressed in epithelial cells of the small intestine and skin in mice and contributes to in vivo epithelial barrier functions.
...
PMID:Metabolism and biological functions of 12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid. 3307 76
