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Query: UNIPROT:P15088 (mast cell)
 14,925 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mast cells have been counted in iliac bone biopsies from patients with chronic renal failure treated by haemodialysis, and attempts made to relate mast cells to the various features of azotaemic renal osteodystrophy. There was a significant increase in the number of marrow mast cells in comparison with controls, and haemodialysis has no favourable effect on the marrow mast cell hyperplasia which occurs in chronic renal failure. There was a general tendency towards greater numbers of mast cells in cases with most marked ostetis fibrosa but it was not possible consistently to relate hyperparathyroidism to mast cell numbers. Patients treated by parathyroidectomy, aluminium hydroxide, or the newer vitamin D metabolites failed to show any consistent fall in marrow mast cell numbers in spite of improvement in the ostetis fibrosa. The number of marrow mast cells was related to the duration of haemodialysis and to the amount of osteoid present and iversely to the percentage mineralization of bone. It was not possible to identify any causal relationship between the presence or severity of osteomalacia and the number of mast cells in the haemodialysed patients although mast cell hyperplasia was also observed in patients with osteomalacia unassociated with renal disease.
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PMID:Iliac bone marrow mast cells in relation to the renal osteodystrophy of patients treated by haemodialysis. 93 6

The authors have endeavoured to determine the place occupied by mast cells in bone tissue from the mode of action on the bone of their secretion products (metachromatic granules, heparin, prostaglandins), from their proliferation in reaction to some bone diseases (secondary mastocytosis) and from the bone lesions associated with systemic mastocytosis. Metachromatic granules are capable of chelating calcium, and heparin and prostaglandins stimulate bone resorption. However, the role of mast cells in bone remodeling through these mechanisms has not yet been demonstrated. Similarly, the significance of mastocytosis secondary to osteomalacia, renal osteodystrophy and ordinary osteoporosis remains hypothetical. Primary bone mastocytosis produces diffuse or circumscribed osteogenic, osteolytic or mixed lesions. While the pathogenesis of osteolytic forms can readily be explained by the actions of heparin and prostaglandins, that of the osteogenic forms is still mysterious. Finally, the histological profile, and even the nosological profile, of mast cell osteoporosis, a diffuse condition recently individualized, remain undetermined.
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PMID:[Mast cells in bone pathology]. 714 58