Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P15088 (mast cell)
 14,925 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

No toluidine blue reactive mast cells are found in the testicular interstitium of neonatal, prepuberal and adult mice, while the cells are present in the testicular interstitium of the human. Using ddY mice, mast cell induction to the testicular interstitium was tried as a model to clarify the cause of idiopathic hypospermatogenesis in male infertility. Transperitoneal left testicular torsion at 360 degrees was carried out to 14 weeks-old ddY mice under ether anesthesia. Mast cell invasion to the contralateral testis was demonstrated 4 weeks after the operation and reached plateau 8-24 weeks postoperatively. These mast cells were round in shape in contrast to those in the epididymis and tunica albuginea which were irregular. Right intact testicular weights were on the same levels as those of control mice and no histological changes including tubular atrophy, Leydig cell degeneration and lymphocyte infiltration were found microscopically. The mechanism of mast cell induction to the contralateral testicular interstitium in this study remained unclear. However, it is suggested that induction of mast cells for a long period within the mouse testicular interstitium could be utilized to pursue the mechanism of idiopathic hypospermatogenesis.
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PMID:[Mast cell induction to the mouse testicular interstitium]. 802 36

The objective of this study was to investigate mast cells and iNOS expression in testis tissue, and to correlate these results with spermatogenic disorders. A total of 136 testicular biopsies were obtained from the testes of 80 patients with infertility. Their age ranged from 21 to 45 years. The biopsy specimens were immunohistochemically stained with antihuman tryptase for mast cells. In each section, all interstitial fields were evaluated for the total number of mast cells as well as the total number of Leydig cells. The number of mast cells per Leydig cell was calculated and recorded as mast cell index. Immunohistochemical iNOS staining was evaluated semiquantitatively according to intensity and the proportion of the stained cells. There was a significant increase of the mast cell index in all groups with testicular disorder compared with normal spermatogenesis group (p < 0.05). Increase of the index was in the order of hypospermatogenesis, maturation arrest and SCO, and index of SCO group was especially higher, i.e, more than twice than other groups. iNOS score was significantly higher in the SCO group than in the men with normal spermatogenesis, hypospermatogenesis, and maturation arrest (p < 0.05). Finally, a significantly statistical correlation was found between the iNOS score and mast cells index (r = 0.758, p = 0.001). Increase of mast cell index was observed in the groups of infertile testis, and high expression of iNOS in Leydig cells was associated with the highest mast cell index in SCO, the lesion with the most severe damage of the germ cell.
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PMID:Relationship between mast cell and iNOS expression in testicular tissue associated with infertility. 1580 70