Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P15088 (mast cell)
 14,925 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The regulatory effects of various endocrine factors on allergic processes have been widely studied. The clinical importance of hyperthyroidism in asthma and in chronic urticaria has been demonstrated in several cases. These observations may be attributed to modulatory effects of thyroid hormones on mast cell releasability and/or on other target organs as blood vessels. To evaluate the effects of thyroid hormones on mast cell releasability and on the cutaneous vasculature, we analyzed the wheal and flare response to compound 48/80, to codeine, and to histamine in patients with hyperthyroidism and in a control group. No significant difference was found between the two groups. We could not demonstrate any in vivo effect of the thyrotoxic state on the cutaneous response to these substances.
 ...
PMID:Cutaneous responses to histamine, compound 48/80 and codeine in patients with hyperthyroidism. 230 20

The present study examines the metabolic changes caused by chronic mast cell degranulation in rats. Three groups of 5 adult rats each were used: 1) rats treated with increasing doses of BW 48/80 (2 to 6 mg kg-1 day-1, ip, for 4 days); 2) a control group receiving daily saline injections, and 3) rats treated with disodium chromoglycate (DCG) (40 mg kg-1 day-1,ip, for 4 days). The third group was included as a control since DCG blocks mast cell degranulation. Saline- and DCG-treated rats showed little differences except for an increase in spleen wet weight and liver glycogen content in the latter. Chronic treatment with compound BW 48/80 resulted in statistically significant changes such as body weight loss, reduction in thymus and spleen wet weights, decrease in spleen protein content, liver glycogen and blood insulin concentrations, increase in plasma free fatty acids concentration and adrenal wet weight compared to control rats. These metabolic changes are similar to those reported for hyperthyroidism and support previous findings on the possible role of mast cells in the control of thyroid function.
 ...
PMID:Hyperthyroid-like metabolic changes induced by chronic administration of compound BW 48/80. 250 80

Flushing disorders with involvement of the gastrointestinal tract represent a heterogeneous group of conditions. In part 1 of this review series, neuroendocrine tumors (NET), mast cell activation disorders (MCAD), and hyperbasophilia were discussed. In this section we discuss the remaining flushing disorders which primarily or secondarily involve the gastrointestinal tract. This includes dumping syndrome, mesenteric traction syndrome, rosacea, hyperthyroidism and thyroid storm, anaphylaxis, panic disorders, paroxysmal extreme pain disorder, and food, alcohol and medications. With the exception of paroxysmal pain disorders, panic disorders and some medications, these disorders presents with dry flushing. A detailed and comprehensive family, social, medical and surgical history, as well as recognizing the presence of other systemic symptoms are important in distinguishing the different disease that cause flushing with gastrointestinal symptoms.
 ...
PMID:Flushing Disorders Associated with Gastrointestinal Symptoms: Part 2, Systemic Miscellaneous Conditions. 2965 May 26