Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P15088 (mast cell)
 14,925 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A standard evaluation of mast cell numbers was performed in 110 cases of cervical precanceroses and carcinomas in comparison with bioptic samples without any pathologic lesion. Pathologic lesions were accompanied by an increase of mast cell numbers--except cases with abnormal epithelium. Peak numbers were found in preinvasive carcinoma. Mast cell numbers in invasive carcinoma were beyond an average level of control samples but obviously under those in preinvasive carcinoma.
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PMID:[Mastocytes in the process of cancerogenesis. II. Precancerous conditions and carcinomas of the uterine cervix]. 379 53

An understanding of the known biologic facts of this disease and methodical evaluation of the individual patient are necessary prerequisites for outlining rational courses of therapy for dogs afflicted with mammary tumors. Because of the common occurrence of multiple tumors arising at various stages of development simultaneously and the heterogeneity of histology of the complex (mixed tissue types) tumors, presurgical biopsy is recommended only in cases in which mast cell tumor or anaplastic carcinoma is suspected. Although investigative work is being performed regarding the efficacy of chemotherapy, radiation therapy, and immunotherapy, surgery still remains the mainstay in treatment of this condition. No one surgical procedure fits the needs of all patients, although it seems logical to remove as much breast tissue as is reasonable in each circumstance owing to the multicentric nature of the disease. Ovariohysterectomy has not been demonstrated to be of value in treatment of dogs with mammary tumors, but it is a markedly effective method of preventing mammary tumors if it is performed before puberty; it is moderately effective if performed before the dog is 21/2 years of age.
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PMID:Canine mammary gland tumors. 389 66

In breast carcinoma metachromasia on staining the primary tumour with toluidine blue is related to mast cell changes and an infiltrative as opposed to an expansive growth form. In 73 patients the presence of metachromasia in the zone of host-tumour interaction, just beyond the edge of the tumour cells, was associated with poor short-term survival, giving greater discrimination than, for example, axillary nodal status or histological grade. 12 of 19 patients with metachromasia in this zone died within 5 years of operation. This indicates that the reaction is not only related to local infiltrative growth, but may also reflect the tumour potential for metastatic spread. In the absence of metachromasia in this zone death occurred mainly in patients with poorly differentiated tumours. The possible mechanisms involved are discussed. It is stressed that stromal metachromasia is not tumour specific, but that in certain areas, under defined circumstances, it may give information of both prognostic and biological interest.
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PMID:Mast cell changes and tumour dissemination in human breast carcinoma. 620 34

A series of 115 female breast carcinomas was studied with special emphasis on the relationships between the hormone receptor (ER and PR) levels and the histological parameters reflecting tumor-host reactivity. Carcinomas were classified according to their nuclear grade (NC) and the stromal host reactions; perivenous lymphocyte infiltration (PVI), lymphocyte (LD), plasma cell (PCI), and mast cell infiltration (MI) were assessed. NG did correlate directly with the ER positivity, but not with the absolute ER values. LI and PCI, but not MI and PVI, showed an inverse relation to the ER values, but not to those of PR. ER and to lesser extent the PR values were higher in postmenopausal than in premenopausal women. The findings are discussed in the light of tumor-host relationships, and conclusion is drawn that the receptor determinations used in connection with the histological evaluation of these parameters (NG especially) are of definite benefit in dividing the breast cancer patients into groups of different expectancy of the future outcome of their disease.
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PMID:Hormone receptor levels related to histological parameters of tumor-host relationships in female breast carcinoma. 628 11

Skin tumors experimentally induced by dimethylbenzanthracene (DMBA) are associated with dense subepithelial accumulations of mast cells. To investigate the sequential changes of the mast cell population during carcinogenesis, and to provide a model with which to examine mast cell proliferation, the back skin of 48 Swiss Webster mice was painted with 0.5% DMBA in benzene twice weekly for 12 weeks. Control and DMBA-treated tissues were processed for histological examination. The observed pattern of tissue changes fell into four phases: a) inflammation and necrosis followed by epithelial regeneration and hyperplasia, b) development of localized regions of acanthosis, c) loss of normal organization with downgrowth of epithelial cells and formation of keratin pearls, d) appearance of well-defined nodules resembling verrucous carcinoma. Subepithelial mast cells varied greatly in number during the above sequence of changes. Dense foci of cells were seen, particularly beneath the regions of hyperplastic epithelium. Mast cells may play a role in abnormal epithelial proliferation and, further, DMBA treatment may provide a suitable model with which to examine the origin and kinetics of mast cells.
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PMID:Sequential histological changes and mast cell response in skin during chemically-induced carcinogenesis. 641 83

In C57BL/6 mice bearing the 3LL carcinoma and in C3H mice bearing the McC3 -1 fibrosarcoma (18th passage), the increase in skin histamine levels was correlated with the increase in mast cell number. The number of cells able to incorporate tritiated thymidine was proportional to the mast cell number. These results strengthen the notion that, in tumour-bearing rodents, the increase in tissue histamine is an active phenomenon.
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PMID:Tissue histamine levels and mast cell numbers in tumour-bearing mice. 673 Nov 80

Mast cell counts on lymph nodes from 64 patients with infiltrating breast carcinoma showed that in the absence of metastases to any of the axillary nodes few mast cells were present. If metastases were present in any of these nodes, both those with and those without tumour showed higher mast cell counts. Thus it seems that it is the presence or absence of tumour in the axilla as a whole, rather than within the individual node, that is associated with the change in mast cell count.
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PMID:Mast cells in the axillary nodes of breast cancer patients. 706 92

Gastrointestinal neoplasms other than lymphosarcomas and mast cell tumors were diagnosed in 44 cats during a 14-year period at the Washington Animal Disease Diagnostic Laboratory. All the tumors were malignant; 31 metastasized or recurred. One cat had fibrosarcoma; another, leiomyosarcoma. The other 42 cats had adenocarcinomas, which were subclassified into three histologic patterns: tubular adenocarcinoma; undifferentiated carcinoma; and mucinous adenocarcinoma. The cats averaged 10.6 years of age. There was no sex predisposition. Siamese cats had a higher frequency of adenocarcinomas than other breeds. Osseous and chondroid metaplasia occurred in nine adenocarcinomas.
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PMID:Nonhematopoietic gastrointestinal neoplasia in cats: a retrospective study of 44 cases. 728 60

Photoradiation therapy, a new method for treatment of solid malignant tumors, depends upon the tumor localization and retention of hematoporphyrin derivative, which is activated in vivo by light in the red region of the spectrum. As currently applied to cutaneous and s.c. lesions, the light dose is limited by both normal tissue reactions and the effective penetration of the light through the tissues. In this report, primary solid malignant lesions in pet cats and dogs have been treated by interstitial photoradiation therapy by applying the activating light from a laser [635 +/- 5 (S. D.) nm] directly into the tumor masses thrugh a 200-micrometer quartz fiber optic. Twelve of 14 lesions (four osteosarcomas, two squamous cell carcinomas, two malignant melanomas, one mast cell sarcoma, one fibrosarcoma, one sebaceous gland sarcoma, and a metastatic prostatic carcinoma) responded to treatment, and three are currently considered permanently controlled at 1 year or more following treatment. This method has not only allowed photoradiation therapy to be applied to some remote lesions but has also nearly eliminated normal tissue effects, thus greatly extending the applicability of this treatment to a wide range of human tumors.
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PMID:Interstitial photoradiation therapy for primary solid tumors in pet cats and dogs. 744 84

We describe the use of tris (2,2'-bipyridine) ruthenium (II) (Rubipy) as a cationic fluorochrome for cytochemical and histochemical studies. After staining with Rubipy, mast cell granules (MCGs) and lymphocyte nuclei (LN) from mouse peritoneal cavity and human breast carcinoma showed intense orange fluorescence and no fading under blue or blue-violet exciting light. Staining at low pH (< 2) or pre-treatment with Al3+ ions strongly diminished the fluorescence of LN, whereas that of MCG was less affected. Ca2+ and Ba2+ ions only diminished MCG fluorescence. Blots of DNA, pectic acid, heparin, and other sulfated polysaccharides stained with Rubipy showed high emission, which was reduced in DNA and pectic acid staining at low pH. Studies with chemically modified heparins suggested that O-sulfates were more important than N-sulfates in Rubipy-heparin interactions. These results are in agreement with an ionic binding mode between Rubipy and heparin. A very suitable method for mast cell detection was found with Mayer's hematoxylin before Rubipy staining, which could be of great value for histopathological studies. This procedure allowed visualization of the mast cells by fluorescence microscopy, and nuclei and tissue morphology were easily visualized under brightfield illumination.
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PMID:Cytochemical application of tris (2,2'-bipyridine) ruthenium (II): fluorescence reaction with sulfated polyanions of mast cell granules. 773 May 92


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