Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P15088 (mast cell)
 14,925 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Tumor angiogenesis factor (TAF) elicits a strong vasoproliferative response when implanted upon the chorioallantoic membrane (CAM) of the chick embryo. This response is first observed stereomicroscopically 2-3 days after implantation. A 40-fold increase in mast cell density is observed within the vicinity of this implant by 24 h. Mast cells that have been isolated from retired breeder Sprague-Dawley rats fail to evoke a vascular reaction when implanted on the CAM. An intermediate role for the mast cell in tumor angiogenesis is suggested.
Int J Cancer 1976 Nov 15
PMID:Mast cells and tumor angiogenesis. 6 25

Twenty-three dogs completed a fractionated course of ionizing radiation therapy for mast cell tumors. In 10 dogs the response was satisfactory, and the tumors were considered controlled 12 months after completion of the prescribed course of therapy. Treatment was considered unsatisfactory for the remaining 13 dogs due to failure to control the tumor locally, generalized metastasis, or both. A dose effect was noted in the response of the tumors to radiation. Of 6 dogs, 5 responded satisfactorily when the tumor dose was 4,000 rads or greater. When the tumor dose was less than 4,000 rads, 5 of 17 dogs responded satisfactorily. The dose calculated to control 50% of the meat cell tumors was 3,625 rads (95% confidence interval: 3,265-4,024 rads). Adverse normal tissue reactions, which consisted of moist desquamation in 10 animals and necrosis in 4, were recorded. The dose calculated to cause desquamation in 50% of the dogs was 3,750 rads (95% confidence interval: 3,348-4,200 rads).
J Natl Cancer Inst 1979 Sep
PMID:Response of canine mast cell tumors to radiation. 11 13

N6,O2'-Dibutyryladenosine cyclic 3',5'-phosphate plus theophylline inhibited the growth of the mouse mast cell tumor line PY 815 both in vivo and in vitro. The inhibitory effect on growth in vitro was rapidly reversed following removal of the drugs. Growth inhibition was accompanied by reduced cell surface activity and increased cell-cell adhesion. The drug-treated cells accumulated distinct membrane-bound granules, which are characteristic of more mature mast cells. Treated cells also developed increased amounts of surface-associated acidic mucopolysaccharides. These results suggest that increased intracellular cyclic adenosine 3':5'-monophosphate causes mouse mastocytoma cells to decrease growth and elicits the expression of a more differentiated mast cell phenotype. The effect of the antileukemia drug, 4'-(9-acridinylamino)methanesulfon-m-anisidine, on cyclic adenosine 3':5'-monophosphate and adenosine 5'-triphosphate in mastocytoma cells is also reported.
Cancer Res 1975 Jun
PMID:Regulation of growth of mouse mastocytoma cells. 16 78

Cell suspensions of the transplantable Furth murine mast cell tumor were separated both by velocity sedimentation in an isokinetic gradient and by isopyknic sedimentation. Prior to separation, the suspension of tumor cells contained 60.3+/-13.1% (S.D.) malignant mast cells, 9.8+/-10.4% lymphocytes, 4.3+/-2.1% granulocytes, 1.7+/-1.9% macrophages, 0.6+/-0.4% unidentified cells, and 22.8+/-8.5% red blood cells. After either isokinetic or isopyknic sedimentation, more than 97% of the nucleated cells in the purest modal fraction were malignant mast cells. Velocity sedimentation in the isokinetic gradient offered several advantages over isopyknic separation of this tumor; namely, in isokinetic sedimentation, the cells are exposed to a lower centrifugal force for a shorter period of time; a much larger proportion of mast cells were in the highly purified zone of the gradient following velocity sedimentation; and lymphocytes were more highly purified (88.9+/-10.1% of the nucleated cells) following velocity sedimentation. Granulocytes and macrophages were purified more than 8-fold over the nucleated cells in the starting sample suspension. The purified cells from this tumor offer the opportunity to study the interactions between highly purified, easily identified, malignant cells and cells that may participate in the defense of the host against cancer.
Cancer Res 1977 Feb
PMID:Separation of lymphocytes and mast cells from the Furth transplantable mast cell tumor in an isokinetic gradient of Ficoll in tissue culture medium. 40 82

Tumors were induced in 46 of 52 female Sprague-Dawley rats by gastric intubation of 5 mg of DMBA, dissolved in 1 ml of sesame oil, given weekly for 5 weeks. From 4 weeks after the final dose tumors were recorded and measured. Bilateral ovariectomy was done 3 days before sacrifice and assay. Excised tumors were immediately immersed in ice-cold Tris-EDTA buffer. Sections were prepared for histological examination. The assay was done by sucrose density centrifugation after administration of (2,4,6,7-tritiated)-estradiol-17beta in vivo 3 minutes before killing, and/or in vitro. For specific estrogen-binding proteins the capacity to bind (tritiated)-estradiol-17beta was not related to the growth characteristics, time of appearance, or time between ovariectomy and assay. Different tumors had estrogen-binding capacities unrelated to the percentage of neoplastic cells in the tumor, amount of inflammation, mast cell infiltration, or presence of fluid-filled cysts. The number of mitoses and the lipid content of the tumors were correlated with the estrogen-binding capacity in that it was lower in tumors with many mitoses and in those with much lipid in the epithelial cells. Of 19 adenocarcinomas, 6 did not regress after ovariectomy. In 5 of the regressed tumors a new growth phase was seen, beginning 2 months after ovariectomy. Tumors encountered, other than mammary adenocarcinomas, were an extraosseous osteosarcoma, fibroadenomas, and zymbal-gland tumors.
Br J Cancer 1977 May
PMID:Morphology, growth characteristics and oestrogen-binding capacity of DMBA-induced mammary tumours from ovariectomized rats. 40 32

Three hundred and two carcinomas of the female breast were studied histologically with special reference to the morphologic aspects of the tumor, its surrounding host tissue and the regional lymph nodes. The nuclear grade of the tumor was positively correlated with the five year survival rate of the patient. Tumor metastases in the regional lymph nodes were observed to be a sign of a poor prognosis. The stromal lymphocyte and mast cell reactions did not correlate with the frequency of nodal metastases or the five year survival rate. Sinus histiocytosis in the lymph nodes was a sign of favorable five year survival because of its presence in cancer-free nodes only. The paracortical activity of the lymph nodes was an important determinant of whether or not tumor metastases appear in the node.
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PMID:Tumor-host interrelationships in carcinoma of the female breast. 66 8

The clinical course of twenty-one patients who presented with life-threatening symptoms, appearing to be allergic in aetiology, is described. In ten of these patients clinical evaluation established a diagnosis, for example: drug allergy, food allergy, a curious form of hospital addiction syndrome, an underlying malignancy, systemic mast cell disease or a complement abnormality. In the remaining subjects, it was found that their condition could be stabilized with sympathomimetics, antihistamines and corticosteroids. In those in whom no aetiology could be found, there was usually a spontaneous subsidence of the frequency and severity of attacks or spontaneous remission. No fatalities occurred.
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PMID:Evaluation of severe (anaphylactic) reactions. 66 3

The serum of rats immunized by MCA sarcoma graft may cause marked degranulation of the mast cells of syngeneic rats sensitized by a homogenate of cancer cells. The serum of immune rats has also caused more limited degranulation in syngeneic rats that have not been previously sensitized. This phenomenon would appear to be explained by a possible cross reaction of antibodies present in the immune sera with the normal histocompatibility antigens expressed on mast cell membranes.
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PMID:[Degranulation of the mast cells of syngeneic rats induced with sera of rats treated with grafts of methylcholanthrene-induced sarcoma]. 69 10

Maternal antibodies can be detected by immunofluorescence techniques on mouse placenta. Following acid elution, it is possible to characterize them as mostly IgG, mainly IgG1. It can be shown that they specifically bind paternal thymocytes and promote allogeneic mast cell degranulation, mainly specifically, but also to a lesser extent non specifically. The prolongation of survival of paternal strain tumor injected into a maternal strain animal demonstrate their enhancing activity.
Bull Cancer
PMID:[Role of facilitating antibodies during pregnancy and growth of tumors]. 99 May 18

Passive immunotherapy was attempted in a patient with mast cell leukemia using antibody against IgE. The results of both in vitro and in vivo studies indicate that although receptor sites for IgE were retained by the malignant mast cell, a secretory defect was present characterized by the spontaneous release of histamine and an impaired secretory response to anti-IgE antibody. Anti-IgE antibody selectively and reproducibly reduced the number of circulating mast cells probably by facilitating their permanent uptake by the reticuloendothelial system. Tolerance was not achieved with high dose deaggregated sheep IgG, nor were we able to confirm the effectivity of immunochemotherapy based on linking chlorambucil to antibody directed against the tumor-associated "antigen" IgE.
Cancer 1976 Feb
PMID:An approach to immunotherapy using antibody to IgE in mast cell leukemia. 108 94


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