Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P15088 (mast cell)
 14,925 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 25-year-old man complained of painless, firm scrotal nodules which increased in number and size for the last 7 years. Physical examination was unremarkable except for many, firm painless nodules near the scrotal raphe. Preoperative diagnosis was multiple scrotal tumors of unknown etiology. Surgical excision was performed under epidural anesthesia. On microscopic examination, the nodules were located in the dermis and composed of calcified material which was positive with the von Kossa calcium stain. There were numerous foreign giant cells and dense fibrosis at the margins of the lesions. Idiopathic calcinosis of the scrotum was the final diagnosis. Although its etiology is unknown, the literature reviewed supported the view that the mast cell accumulation and its degranulation are related to idiopathic calcinosis of the scrotum.
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PMID:[Idiopathic calcinosis of the scrotum: a case report]. 342 27

Mast cells participate in experimental calcinosis. Skin from patients with urticaria pigmentosa (cutaneous mastocytosis) calcifies in vitro. In the present report, the nature of the calcium deposit was studied by electron optical techniques. The cultured mast cells of urticaria pigmentosa skin were surrounded by a large number of round bodies with an average diameter of 200-300 nm. Most of the round bodies were membrane bounded, while a few contained lamellar structures. These bodies may represent matrix vesicles as seen in calcifying hard tissues and/or may be remnants of mast cell granules. The calcified deposits were located on the round bodies, collagen fibrils and elastic matrix. Electron diffraction and X-ray microanalysis demonstrated that the deposits consisted of crystalline calcium apatite.
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PMID:Calcification of cultured urticaria pigmentosa skin. An electron optical study of the calcium-apatite deposition. 742 98

Calcium antagonists (CAs) or calcium-channel blockers are a common group of antihypertensive medications. These drugs have the property of blocking the calcium channels of vascular and cardiac smooth muscle fibers. Some of these drugs may inhibit the growth and proliferation of vascular smooth muscle cells and fibroblasts, and inhibit the synthesis of extracellular-matrix proteins (collagen, fibronectin, proteoglycans). Other CAs also have immunomodulatory or dysregulatory effects on lymphocytes and can suppress superoxide generation and phagocytic action of neutrophils. Moreover mast cell degranulation and platelet aggregation may also be impaired. On account of these properties, calcium antagonists have also been used for the prevention and treatment of various dermatologic diseases such as erythromelalgia, idiopathic- or CREST-related calcinosis cutis, primary and secondary Raynaud phenomenon, chilblains, chronic anal fissures, keloids, and burn scars. They are also used for prevention of skin flap necrosis in experimental models. Calcium antagonists, apart from their well known and established antihypertensive action, should also be considered as possible therapy for several dermatologic diseases.
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PMID:Calcium antagonists in dermatology: a review of the evidence and research-based studies. 1615 Feb 16