Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P14784 (
IL-2 receptor
)
3,849
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Blood proteases regulate cellular growth through the recognition and signaling properties of specialized membrane receptors. Previous studies have identified a novel lymphocyte activation-dependent antigen, denominated
effector cell protease receptor-1
(
EPR-1
), which binds the coagulation protease factor Xa on various leukocyte subsets. Here we show that occupancy of
EPR-1
with physiologic concentrations of factor Xa (15-75 nM), or with "surrogate" monoclonal antibody ligands, stimulates proliferation of both T and B lymphocyte subsets and augments CD3-dependent lymphocyte proliferation. At suboptimal responder cell concentrations, ligation of
EPR-1
costimulates lymphocyte proliferation in the presence of accessory signals, i.e., phorbol ester, IL-2. At higher responder cell concentrations, occupancy of
EPR-1
per se is sufficient to initiate lymphocyte proliferation.
EPR-1
-dependent T cell activation is associated with early surface expression of
IL-2 receptor
on target cells, thus increasing by five- to eightfold their mitogenic responsiveness to very low doses of IL-2 (0.2 U/ml). Consistent with a postulated role in transmembrane signal transduction, cross-linking of
EPR-1
transiently increases cytosolic free [Ca2+]i in single adherent T cells. These findings suggest that proteases ubiquitously generated in vivo might contribute a regulatory mechanism of cytokine- or antigen receptor-dependent T cell activation and identify
EPR-1
as a novel signal-transducing molecule of lymphocyte stimulation.
...
PMID:Protease-dependent T cell activation: ligation of effector cell protease receptor-1 (EPR-1) stimulates lymphocyte proliferation. 818 Oct 72
