Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P14784 (IL-2 receptor)
 3,849 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

By using ELISA and assay of MTT participating in IL-6 dependent cell clone. The authors measured the circulating levels of soluble IL-2 receptor (sIL-2R) and IL-6 in patients undergoing hemodialysis (HD). Alterations of the above-mentioned parameters before and after a three-month course of treatment with Chinese drug Epimedium sagittatum on the same HD patients. It is confirmed that in patients with end-stage renal failure (ESRF), sIL-2R level elevated significantly, while IL-6 level decreased apparently (P < 0.01). Furthermore, levels of both sIL-2R and IL-6 could be restored to normal after treatment with Epimedium sagittatum. These findings indicated not only the presence of immunodeficiency in ESRF, but also the effectiveness of regulation with Chinese drug Epimedium sagittatum.
Zhonghua Nei Ke Za Zhi 1995 Feb
PMID:[Effect of epimedium sagittatum on soluble IL-2 receptor and IL-6 levels in patients undergoing hemodialysis]. 779 53

To study the functional state as well as the relation-ship between eosinophil and T lymphocyte in the asthmatics, the authors measured the eosinophil density of blood with percoll, the level of serum eosinophil cation protein (ECP) with radioimmunoassay and soluble IL-2 receptor (sIL-2R) concentration with ELISA. The results revealed that the proportion of hypodense eosinophil and the levels of serum ECP and sIL-2R were 36.3% +/- 14.80%, 10.74 +/- 7.22 mg/L and 0.33% +/- 10 U/L respectively in asthmatics, being significantly higher than those in normal subjects (14.71% +/- 8.20%, 6.93 +/- 4.91 mg/L, 0.13 +/- 0.03 U/L, respectively, P < 0.05 in all). There is remarkable correlation between any two of the three parameters (r = 0.40, 0.37, 0.39, respectively, P < 0.05). It is suggested that eosinophil activation is associated with T lymphocyte activation, both may be involved in the pathogenesis of asthma.
Zhonghua Nei Ke Za Zhi 1995 Dec
PMID:[Changes in serum eosinophil cation protein level and blood eosinophil density in patients with asthma]. 873 55