Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P14784 (
IL-2 receptor
)
3,849
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
There is growing evidence that immunocompetent cells are involved in the pathogenesis of
chronic pancreatitis
. Using a model of
chronic pancreatitis
induced by dibutyltin dichloride (DBTC) in rats, we have immunohistochemically phenotyped the infiltrating T lymphocytes, CD45RC+ cells, macrophages, as well as the
IL-2 receptor
as an activation marker during a time course of two months. In addition, the expression of CD44, of the integrin component CD18, and of MHC class II was determined. Furthermore, the isoforms of CD45 which are generated by alternative mRNA splicing were analysed using reverse transcription followed by the polymerase chain reaction-technique (RT-PCR). The pattern of the local leukocytes in the DBTC pancreatitis suggests that the acute unspecific inflammation is followed by an activation of T lymphocytes resulting in the chronic course of the disease.
...
PMID:Persistence of memory type lymphocytes in an experimental model of chronic pancreatitis in rats. 1203 Apr 36
