Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
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Target Concepts:
Gene/Protein
Disease
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Enzyme
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Query: UNIPROT:P14784 (
IL-2 receptor
)
3,849
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Cell-mediated immunological function was studied in 18 patients with
dilated cardiomyopathy
(
DCM
) making use of peripheral blood lymphocytes (PBL). The results were as follows: 1) Blastoid transformation of PBL stimulated with phytohemagglutinin (PHA) was significantly suppressed in patients with
DCM
compared with normal controls (p less than 0.01). 2) The T-cell subset ratio of Leu-3a-positive cells to Leu-2a-positive cells was significantly higher in patients with
DCM
than that in the control group (p less than 0.05). 3) Interleukin-2 (IL-2) production of PBL under PHA stimulation was enhanced significantly in patients with
DCM
(p less than 0.05). 4)
IL-2 receptor
-positive cells were significantly fewer in number in patients with
DCM
than in controls (p less than 0.05). These results suggest that immunological disorders including changes in the IL-2 system are present in some patients with
DCM
and may play a role in the occurrence of
DCM
.
...
PMID:Immunological disorders in patients with dilated cardiomyopathy. With special reference to the production of interleukin-2 and the expression of interleukin-2 receptors in the patients' peripheral blood lymphocytes. 263 33
Expression of interleukin 2 (IL-2) receptor on peripheral blood lymphocytes after stimulation with concanavalin A (Con A) or anti-T3 monoclonal antibody was analyzed in patients with
dilated cardiomyopathy
(
DCM
) in order to clarify the abnormalities of lymphocyte activation mechanism in
DCM
. The expression of
IL-2 receptor
after the stimulation with either Con A or anti-T3 monoclonal antibody was found to be reduced in the patients with
DCM
when the results were compared with those of controls. A significant correlation was noticed between the expression of
IL-2 receptor
after Con A stimulation and T4+/T8+ cell ratio, and between the expression of
IL-2 receptor
after anti-T3 monoclonal antibody stimulation and the left ventricular end-diastolic pressure (LVEDP). The results suggest that there are abnormalities of lymphocyte activation in
DCM
and that the alteration may be associated with the cause or clinical conditions of
DCM
.
...
PMID:Surface marker studies on activated peripheral blood lymphocytes in idiopathic dilated cardiomyopathy. 311 2
