Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P11684 (Uteroglobin)
 114 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Uteroglobin (blastokinin), a widely studied protein in uterine secretions, is secreted by the glandular epithelium of the uterus in species such as deer or rabbits. It is hypothesized that uteroglobin transports progesterone in uterine secretions implying that protein is produced in response to progesterone, and then it transports the steroid through the uterine lumen. There has been disagreement on the ability of uteroglobin to transport much progesterone and on the strength of binding of the steroid to the protein. Assays of steroids in rabbit uterine fluids hve shown that progesterone levels can be high and follow closely the values for uteroglobin. Most progesterone appears bound to protein; neither estradiol-17beta nor 17alpha-hydroxyprogesterone was detectable in the flushings suggesting that the binding of steroids is highly specific. The debate over the role of uteroglobin continues; there is a possiblity that other proteins in the human uterus similar to uteroglobins may be present and may offer a useful approach for suppressing fertility.
 ...
PMID:Steroids and the secretion of fluid by the uterus. 1233 13