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Query: UNIPROT:P11684 (Uteroglobin)
 114 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Uteroglobin (blastokinin), a widely studied protein in uterine secretions, is secreted by the glandular epithelium of the uterus in species such as deer or rabbits. It is hypothesized that uteroglobin transports progesterone in uterine secretions implying that protein is produced in response to progesterone, and then it transports the steroid through the uterine lumen. There has been disagreement on the ability of uteroglobin to transport much progesterone and on the strength of binding of the steroid to the protein. Assays of steroids in rabbit uterine fluids hve shown that progesterone levels can be high and follow closely the values for uteroglobin. Most progesterone appears bound to protein; neither estradiol-17beta nor 17alpha-hydroxyprogesterone was detectable in the flushings suggesting that the binding of steroids is highly specific. The debate over the role of uteroglobin continues; there is a possiblity that other proteins in the human uterus similar to uteroglobins may be present and may offer a useful approach for suppressing fertility.
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PMID:Steroids and the secretion of fluid by the uterus. 1233 13

Previous studies have shown that the equine uterus produces many progesterone-dependent proteins throughout gestation. In particular, uterocalin and uteroferrin are detectable using electrophoresis or blot analyses but information regarding the immunohistochemical placental distribution of these two proteins is rare and information regarding uteroglobin is still lacking. The aim of the present study was to co-immunolocalise these three secretory proteins in the mare's uterus throughout gestation in an effort to understand their functional role in the maintenance of pregnancy. Therefore, endometrial biopsy samples were obtained from 20 pregnant mares between 16 and 309 days of gestation and labelled immunohistochemically for uteroglobin, uteroferrin and uterocalin. Uteroferrin remained detectable in almost every endometrial gland at all stages but with an increase in staining intensity as gestation advanced. The most progesterone-dependent protein, uterocalin, showed variable staining throughout gestation with the most intense labelling in early pregnancy and during the period of endometrial cup reaction. Uteroglobin secretion was only detectable in traces and only in individual glands throughout gestation. The results indicate that uterocalin and uteroferrin, but not uteroglobin, may play important roles in supplying nutrients for the conceptus, thereby contributing to the maintenance of pregnancy. However, further investigations are necessary to understand the role of uteroglobin during gestation.
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PMID:Immunolocalisation of the uterine secretory proteins uterocalin, uteroferrin and uteroglobin in the mare's uterus and placenta throughout pregnancy. 1854 36

Secretoglobin family 1A member 1 (SCGB 1A1) is a small protein mainly secreted by mucosal epithelial cells of the lungs and uterus. SCGB 1A1, also known as club (Clara) cell secretory protein, represents a major constituent of airway surface fluid. The protein has anti-inflammatory properties, and its concentration is reduced in equine recurrent airway obstruction (RAO) and human asthma. RAO is characterized by reversible airway obstruction, bronchoconstriction and neutrophilic inflammation. Direct effects of SCGB 1A1 on neutrophil functions are unknown. We have recently identified that the SCGB1A1 gene is triplicated in equids and gives rise to two distinct proteins. In this study we produced the endogenously expressed forms of SCGBs (SCGB 1A1 and 1A1A) as recombinant proteins, and analyzed their effects on reactive oxygen species production, phagocytosis, chemotaxis and neutrophil extracellular trap (NET) formation ex vivo. We further evaluated whether NETs are present in vivo in control and inflamed lungs. Our data show that SCGB 1A1A but not SCGB 1A1 increase neutrophil oxidative burst and phagocytosis; and that both proteins markedly reduce neutrophil chemotaxis. SCGB 1A1A reduced chemotaxis significantly more than SCGB 1A1. NET formation was significantly reduced in a time- and concentration-dependent manner by SCGB 1A1 and 1A1A. SCGB mRNA in bronchial biopsies, and protein concentration in bronchoalveolar lavage fluid, was lower in horses with RAO. NETs were present in bronchoalveolar lavage fluid from horses with exacerbated RAO, but not in fluid from horses with RAO in remission or in challenged healthy horses. These findings indicate that SCGB 1A1 and 1A1A have overlapping and diverging functions. Considering disparities in the relative abundance of SCGB 1A1 and 1A1A in airway secretions of animals with RAO suggests that these functional differences may contribute to the pathogenesis of RAO and other neutrophilic inflammatory lung diseases.
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PMID:Secretoglobin 1A1 and 1A1A differentially regulate neutrophil reactive oxygen species production, phagocytosis and extracellular trap formation. 2477 50

Between the 3rd and 6th day post coitum the dry substance of uterine fluid contains nearly 60% peptide chains, on the 6th day 19 h p.c. only 35%. The remaining 40 and 65% resp. consist mainly of carbohydrates (cf. III.1). By means of disc electrophoresis, thin layer chromatography following hydrolysis and molecular sieve chromatography, we were able to characterize 4 uterine specific proteins, 2 of which are carbohydrate rich glycoproteins. Their relative concentrations were determined between 0 and 8 day p.c. (of. III.2): Glycoprotein I can already be found during oestrus. Its concentration increases slightly from the 3rd to the 5th day p.c., more rapidly up to the 6th day 6 h p.c., and decreases later (of.III.2b). The molecular weight is estimated to be around 50,000 (cf.III.4). Postalbumin as well as Uteroglobin can be found shortly after ovulation. Its concentration stays nearly constant between 3rd and 6th day p.c., and decreases during the 6th day p.c. (of.III.2b). Its molecular weight is in the same range as that of Uteroglobin, nearly 30,000 (of.III.4. Uteroglobin is most probably free of carbohydrates. Its concentration increases rapidly between 16 and 40 h p.c., slightly until the 5th day p.c., and decreases later (cf.III.2b). At 6th day p.c. about 50% of the peptide chains of uterine fluid are Uteroglobin (cf.III.2.g). Glycoprotein II is not secreted before the 6th day p.c. It has a comparativly high content of galactose (cf.III.3.d). Its concentration increases rapidly during the 6th day p.c. (cf.III.2.b). The moleculare weight is higher than 70,000 (cf.III. 4).These proteins and glycoproteins have also been found inblastocoelic fluid after the 5th day p.c. (cf.III.2.c).Aftersuperovulation induced by hormones, and natural mating, the pregnancy specific protein pattern is not fully developed (cf.III.2.d). Inpseudopregnancy, triggered by mating with vasectomized males, the same proteins as in normal pregnancy were found from the 6th day 6 h to the 6th day 19 h p.c. If no blastocysts are implanted, the protein pattern of the 6th day 19 h p.c. persists nearly unchanged until the 9th day p.c. (cf.III.2.e).Duringimplantation uterus and blastocyst lumens are filled with serum proteins, which tend to cover up the secretion proteins (cf.III.2.f).9 constituents of carbohydrates could be identified in uterine fluid. There was no evidence for freemonohexoses, particularly free glucose. Theoligomere carbohydrates were free or bound to proteins (cf.III.3.). We were able to separate Glycoprotein I, Glycoprotein II, Albumin + Uteroglobin with Sephadex G 150 and G 75 SF (cf.III.4).21 freeamino acids were found in uterine and blastocoelic fluid by means of thin layer chromatography. The concentrations of amino acids in uterine fluid were comparable to those of serum. The dry substance of uterine fluid contains more glycine, alanine, glutamic acid and aspartic acid than that of serum (cf.III.5).The possible role of amino acids in thenutrition of the blastocyst and the possible influence of uterine specific proteins and glycoproteins onnutrition and morphogenesis of the rabbit embryo were discussed.
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PMID:[Studies of uterine specific glycoproteins during early pregnancy of the rabbitOryctolagus cuniculus]. 2830 64


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