Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P11684 (Uteroglobin)
 114 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A sensitive latex particle assay has been developed to study the occurrence of protein 1 in human urine. The coefficients of variation (CVs) of the method which is fully automated vary between 3 and 11.5%. The assayable concentration range is 0.3 to 40 micrograms/l. Protein 1 is clearly a sex-dependent protein. In contrast to urinary retinol-binding protein (RBP) which shows no variation with age or sex, protein 1 is excreted in greater amounts in males from the puberty. In adults, the mean concentration of protein 1 in urine of men is approximately 5 times that of women. In the urine from both sexes, protein 1 occurs as a single component with a Mr around 21,000 and an pI of about 4.8. Protein 1 is correlated with RBP in the urine from female or male patients with impaired proximal tubular function, which suggests that it is handled by the kidney in a similar manner as RBP. Diabetics, however, show elevations of urinary protein 1 which do not correlate with the RBP excretion but with the albuminuria. A competition between albumin and protein 1 for renal tubular uptake might explain this paradoxical behaviour of protein 1 in the course of diabetic nephropathy.
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PMID:Determination by latex immunoassay of protein 1 in normal and pathological urine. 175 96

One hundred male insulin-dependent diabetic patients, aged 16 to 85 (mean 51.9) years, with albumin excretion ranging from normal to gross excess were examined for glomerular and tubular functional alterations by estimating urinary levels of albumin and indicator proteins of tubular damage. Urine protein 1 (UP1), a newly-discovered low-molecular weight alpha-2 glycomicroglobulin, together with alpha 1-microglobulin was used to assess tubular function. 19% of the patients showed increased albumin excretion with normal levels of tubular proteins (glomerular proteinuria), 11% excreted only tubular proteins in excess (tubular proteinuria), while 40% had a mixed pattern of both increased albumin and tubular proteins (glomerulotubular or mixed proteinuria). 30% had normal albumin and tubular protein excretion in urine. UP1 was found to be a more sensitive indicator of tubular abnormality than alpha 1-microglobulin. It is concluded that, although glomerular changes may be responsible for the proteinuria seen in most diabetics (mixed proteinuria), in a small but significant proportion of diabetics, tubular functional alteration may occur before, or in the absence of, glomerular dysfunction, and may warn of subclinical tubular abnormality. This finding may have a direct bearing on the development and course of progression of diabetic nephropathy, and may question the reliability of the present prognostic interpretation of microalbuminuria.
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PMID:The use of urine protein 1 as an indicator of renal tubular function in type I (insulin-dependent) diabetes. 763 47