Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P11021 (
BiP
)
2,049
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Presenilin 1
(
PS1
), a polytopic membrane protein, has a critical role in the trafficking and proteolysis of a selected set of transmembrane proteins. The vast majority of individuals affected with early onset familial Alzheimer's disease (FAD) carry missense mutations in
PS1
. Two studies have suggested that loss of
PS1
function, or expression of FAD-linked
PS1
variants, compromises the mammalian unfolded-protein response (UPR), and we sought to evaluate the potential role of
PS1
in the mammalian UPR. Here we show that that neither the endoplasmic reticulum (ER) stress-induced accumulation of
BiP
and CHOP messenger RNA, nor the activation of ER stress kinases IRE1alpha and PERK, is compromised in cells lacking both
PS1
and PS2 or in cells expressing FAD-linked
PS1
variants. We also show that the levels of
BiP
are not significantly different in the brains of individuals with sporadic Alzheimer's disease or
PS1
-mediated FAD to levels in control brains. Our findings provide evidence that neither loss of
PS1
and PS2 function, nor expression of
PS1
variants, has a discernable impact on ER stress-mediated induction of the several established 'readouts' of the UPR pathway.
...
PMID:Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression. 1114 49
