Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P11021 (
BiP
)
2,049
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
BiP
(grp78) is a chaperone protein which can also regulate the unfolded protein response of the cell. Levels of
BiP
increased in cells infected by the small plaque producing, cell associated, neuroinvasive strains of HSV-1 (
SP7
, 490) but decreased in cells infected with KOS, a large plaque, attenuated strain.
BiP protein
synthesis continued early in infection and
BiP
was sequestered and its degradation was limited during
SP7
infection.
BiP protein
synthesis stopped and the protein was degraded in KOS infected cells. These viral strain dependent differences in
BiP
concentration may influence other aspects of the viral interaction with the target cell and its host.
...
PMID:Changes in BiP (GRP78) levels upon HSV-1 infection are strain dependent. 1141 Mar 13
