Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P11021 (
BiP
)
2,049
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
B/K protein
is a newly identified member of double C2-like domain protein family. We examined the expression of
B/K protein
in the hippocampus of kainate-induced rat seizure model. Intraperitoneal injection of kainate increased the immunoreactivity to
B/K protein
in the CA1 to CA3 of the hippocampus.
B/K protein
expression began to increase at 6 h, reached the maximum at 12 h, and then returned nearly to the normal level at 72 h after the injection of kainate (12 mg/kg), and it was also dependent on the dose of kainate between 4 and 16 mg/kg. In electron microscopic and subcellular fractionation studies,
B/K protein
was localized in the endoplasmic reticulum (ER) of the hippocampus. Kainate also induced the expression of
BiP
, a typical ER stress marker protein, in the hippocampus and the cortex, and it was coexpressed with
B/K protein
. Moreover, thapsigargin-induced ER stress caused upregulation of
B/K protein
expression in PC12 cells. In conclusion, our data showing the induction of both
B/K protein
expression and ER stress response in the hippocampus of kainate seizure model, and ER-specific expression and ER stress-induced expression of B/K strongly suggest the possible role of
B/K protein
in epileptogenesis or epilepsy-induced neuronal damage.
...
PMID:Expression of B/K protein in the hippocampus of kainate-induced rat seizure model. 1475 99
