Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P10721 (c-kit)
 6,575 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
c-kit 6575
stem cell factor 1127
CD34 821
tyrosine kinase 671
CD117 541
mast cell 538
Sep 447
cytokine 422
Mol 403
receptor tyrosine kinase 390
KIT 321
proto-oncogene 313
erythroid 302
lymphoid 290
IL-3 255
CD45 253
SCF 232
mast cell growth factor 225
kit 225
vimentin 218
tyrosine kinase receptor 210
platelet-derived growth factor receptor 196
desmin 165
IL-6 163
granulocyte 155
p53 147
erythropoietin 139
PDGFR 137
GM-CSF 135
smooth muscle actin 133
CD4 130
gut 123
granulocyte-macrophage colony-stimulating factor 114
vascular endothelial growth factor 113
macrophage colony-stimulating factor 111
CD31 110
thymus 107
VEGFR2 106
collagen 104
IgE 100
VEGF 98
PDGF 97
IL-7 96
platelet-derived growth factor 95
Ki-67 92
CD44 90
Thy-1 90
IL-4 89
CD8 86
c-fms 84
S100 83
CSF 82
granulocyte colony-stimulating factor 81
SMA 80
CXCR4 79
epidermal growth factor receptor 78
PDGFRA 78
p56lck 78
CD11b 77
granulocyte-macrophage 76
thrombopoietin 75
EGFR 75
FLT3 73
megakaryocyte 72
CD133 72
insulin 72
membrane-bound 71
CD25 71
cytokeratin 71
vascular endothelial growth factor receptor 69
G-CSF 65
Bcl-2 65
BRAF 64
bcl-2 64
ABL 63
AKT 63
TNF 62
BCR 61
alpha-smooth muscle actin 58
CD38 57
hematopoietic stem and progenitor cells 57
Flt3 ligand 57
mTOR 57
chymase 56
PI3K 55
c-Met 54
interleukin-6 54
MAPK 53
CD56 53
OCT4 52
CXCL12 51
CD33 51
ATP 51
transmembrane receptor 51
GIST 50
IL-10 49
CD19 48
ERK 48
TNF-alpha 48
HLA-DR 48
chemokine 48
nestin 47
CD90 47
cytokeratin 19 47
Interleukin-3 47
tumor necrosis factor 47
fibronectin 47
HER2 46
CD10 46
IL-5 46
CD105 45
interferon 44
c-myc 44
caspase-3 43
CD43 43
CD68 42
p38 41
phosphatidylinositol 3-kinase 41
IL-2 40
KDR 40
AE1 39
VEGFR-1 39
AML 39
IFN 39
Cytokine 39
CD41 39
MEK 38
KIT protein 38
catenin 38
substance P 38
albumin 37
proliferating cell nuclear antigen 37
STAT5 37
p21 37
platelet-derived growth factor receptor alpha 37
alkaline phosphatase 37
synaptophysin 37
HSC 37
estrogen receptor 36
She 36
glial fibrillary acidic protein 36
vascular cell adhesion molecule-1 36
bcr 36
p16 35
IL-11 35
hepatocyte growth factor 34
PU.1 34
CD13 34
cytokine receptor 34
CD14 34
Oct4 33
cyclin D1 33
threonine 33
TCR 32
GATA-1 32
myeloperoxidase 31
alpha-fetoprotein 31
transferrin receptor 31
EGF 31
neuron-specific enolase 31
more...
Disease
tumor 1148
cancer 826
gastrointestinal stromal tumor 381
stromal tumors 371
leukemia 298
acute myeloid leukemia 263
mastocytosis 212
chronic myeloid leukemia 178
melanoma 164
carcinoma 155
metastases 155
tumorigenesis 108
anemia 106
myocardial infarction 106
sarcoma 97
tumor growth 90
lymphoma 89
breast cancer 79
myelodysplastic syndrome 67
Leukemia 66
renal cell carcinoma 66
heart failure 65
mastocytoma 64
ABL 63
diabetes 59
adenocarcinoma 56
uterus 55
asthma 50
ischemia 48
ICC 47
leukemogenesis 47
ICC 47
SCID 46
carcinogenesis 45
myeloproliferative disorders 45
hepatocellular carcinoma 44
tumor progression 44
lung cancer 43
acute lymphoblastic leukemia 40
leiomyoma 38
Mastocytosis 37
seminoma 37
hypertension 37
leiomyosarcoma 37
primary tumor 36
Melanoma 34
metastatic melanoma 34
acute leukemia 33
liver metastases 32
small cell lung cancer 31
colorectal cancer 30
myeloid leukemia 30
mast cell leukemia 29
squamous cell carcinoma 29
tumor angiogenesis 29
neuroblastoma 29
multiple myeloma 28
schwannoma 26
lung carcinoma 26
WT1 26
hematologic malignancies 25
solid tumor 25
ovarian cancer 25
neurofibromatosis type 1 25
infertility 24
erythroleukemia 23
urticaria pigmentosa 23
NOD 23
eosinophilia 23
non-small cell lung cancer 23
glioma 23
glioblastoma 22
prostate cancer 22
thrombocytopenia 22
gastric cancer 22
myelosuppression 21
PBT 21
Systemic mastocytosis 21
anaphylaxis 21
colon cancer 20
rare disease 20
acute myocardial infarction 19
dysplasia 18
metastatic renal cell carcinoma 18
blast crisis 18
MCF 17
Ewing's sarcoma 17
EMA 17
chronic myelomonocytic leukemia 17
Hodgkin's disease 16
HGF 16
atherosclerosis 16
male infertility 16
cardiovascular disease 16
retinoblastoma 16
vitiligo 16
myocardial ischemia 16
rheumatoid arthritis 15
DBA 15
SEM 15
acute promyelocytic leukemia 15
Cutaneous mastocytosis 15
teratoma 15
aggression 15
lymphoblastic leukemia 14
mole 14
PSS 14
Kaposi's sarcoma 14
aplastic anemia 14
macrocytic anemia 14
rash 14
neuroendocrine tumor 14
genetic disorder 14
T-cell acute lymphoblastic leukemia 14
neurofibromatosis 14
osteosarcoma 14
neoplastic transformation 13
aggressiveness 13
testicular cancer 13
APC 13
FDC 13
B-cell lymphoma 13
carcinosarcoma 13
angiosarcoma 13
Fanconi 13
immunodeficiency 13
thymic carcinoma 13
Testes 13
epithelial ovarian cancer 13
desmoid 12
colitis 12
dysphagia 12
Adenoid cystic carcinoma 12
neutropenia 12
leukopenia 12
pulmonary hypertension 12
germinoma 11
Adhesion 11
Crohn's disease 11
ischemic cardiomyopathy 11
autoimmune disease 11
minimal residual disease 11
dysgerminoma 11
dermatofibrosarcoma protuberans 11
CAM 11
hyperglycemia 11
neuroendocrine carcinoma 11
liver cancer 11
depression 11
pertussis 11
embryonal carcinoma 10
synovial sarcoma 10
HIV 10
Blocking 10
primitive neuroectodermal tumor 10
HPP 10
inflammatory bowel disease 10
pruritus 10
paraganglioma 10
premature ovarian failure 10
more...
Symptom
abdominal pain 53
diarrhea 32
constipation 31
fatigue 25
pain 21
splenomegaly 19
functional recovery 18
nausea 16
vomiting 15
anorexia 13
exhaustion 11
weakness 10
dyspnea 9
headache 9
HSA 9
Spotting 8
flushing 7
starvation 7
anesthesia 7
hepatosplenomegaly 6
syncope 6
back pain 6
discomfort 6
discomfort 6
dizziness 5
collapse 5
thinning 5
respiratory distress 5
lethargy 4
hepatomegaly 4
pelvic pain 4
bone pain 4
acute abdominal pain 3
Darier's sign 3
chest pain 3
flank pain 3
seizures 3
epigastric pain 3
cough 3
abdominal discomfort 3
hyperoxia 3
skin irritation 2
decreased appetite 2
dysuria 2
tenesmus 2
hip pain 2
asthenia 2
colic 2
acute abdomen 2
ataxia 2
nausea and vomiting 2
numbness 2
chronic constipation 2
Welt 2
periorbital edema 2
hoarseness 2
bloating 2
urinary frequency 2
dry eye 1
shortness of breath 1
DNA marker 1
acute stress 1
sleepiness 1
acidity 1
cerebellar ataxia 1
female puberty 1
dyschezia 1
regurgitation 1
memory loss 1
tense 1
acute pain 1
paresthesia 1
emaciation 1
chills 1
anal pain 1
polyuria 1
lightheadedness 1
consciousness disturbance 1
polydipsia 1
fever of unknown origin 1
nasal discharge 1
myalgia 1
leg edema 1
abdominal fullness 1
ophthalmoplegia 1
male subfertility 1
erythema 1
stomach pain 1
shoulder pain 1
intestinal bleeding 1
cyanosis 1
low back pain 1
Drug
Imatinib 255
Gleevec 198
CSF 179
Dermatol 116
G-CSF 65
IL-2 40
IL-11 35
IFN-gamma 25
Sorafenib 22
p75 16
lysine 13
Dasatinib 13
CAM 13
Cardiovasc 13
Asn 11
CTX 11
ETS 10
caffeine 10
Leaf 9
TEL 9
MAP 9
Gastro 8
MDS 8
Asthma 8
Herceptin 8
ABC 7
Paraffin 6
Gel 6
Histamine 6
Axitinib 6
G418 5
EML 5
Bevacizumab 5
Activin 4
Erlotinib 4
Midostaurin 4
uPA 4
Monit 4
Bisacodyl 3
ROS 3
CTX 3
Adriamycin 3
Ipilimumab 3
Cetuximab 3
Vatalanib 3
DNase I 3
Portal 3
CTX 3
Rosuvastatin 3
ROC 3
Atropine 3
TAT 3
Angiotensin II 3
TAC 3
Itraconazole 3
PTH 2
CoCl2 2
anti-CD33 2
Ethanol 2
SMP 2
Fluorescein 2
LCM 2
Fructose 2
Sunitinib malate 2
Gefitinib 2
Retinoic acid 2
Albumin 2
Taxol 2
Simvastatin 2
Nephron 2
AIC 2
Tarceva 2
Nexavar 2
Mutagen 2
PTC 2
CoCl2 2
PDL 2
ascorbate 2
Methylcellulose 2
KGF 2
ICI 2
Bortezomib 2
LCM 2
Tandutinib 2
Irinotecan 1
Emodin 1
Ketotifen 1
lactose 1
NVP 1
Fraction 1
Fragment 1
Isotretinoin 1
Fludarabine 1
Docetaxel 1
Sonazoid 1
-deoxyadenosine 1
HCG 1
Emodin 1
nitroglycerin 1
Lupron 1
ENT 1
Peridex 1
TAK 1
Lestaurtinib 1
Allergen 1
Motesanib 1
DMAP 1
Alanine 1
Lenalidomide 1
Captopril 1
CTC 1
Retinoic Acid 1
Codeine 1
Hymenialdisine 1
Beraprost sodium 1
Sodium nitroprusside 1
balanced salt solution 1
Nitric Oxide 1
Mirtazapine 1
ETA 1
Zaditen 1
DM1 1
Etoposide 1
TTC 1
Beraprost 1
CCL 1
Tranilast 1
ZnO 1
RFP 1
MDM 1
EE2 1
Olmesartan 1
NOV 1
MTC 1
Pravastatin 1
Trabectedin 1
Giardiasis 1
NADH 1
Taxotere 1
Norplant 1
CTT 1
CPT-11 1
PCB 1
Methylene blue 1
Heme 1
Codeine 1
CTC 1
CTA 1
Glide 1
Doxycycline 1
Phentolamine 1
IFN-beta 1
Aminoguanidine 1
Reserpine 1
Prednisolone 1
Prednisone 1
Ranitidine 1
Miltefosine 1
Enzyme
ERK 832
focal adhesion kinase 244
mitogen-activated protein kinase 159
tryptase 147
trypsin 123
protein kinase 76
protein kinase C 57
reverse transcriptase 56
chymase 55
peroxidase 46
CD10 46
AMPK 44
MEK 42
phosphatidylinositol 3-kinase 41
Thy1 40
alkaline phosphatase 37
caspase-3 35
CD13 34
tyrosinase 29
luciferase 22
plasmin 18
RNase 18
RNase 17
phospholipase C 17
NOS 17
RNA polymerase 17
TdT 16
APC 15
DCF 14
phosphoinositide 3-kinase 14
transcriptase 14
hexosaminidase 14
thyroid peroxidase 14
acetylcholinesterase 13
thrombin 13
glutathione S-transferase 13
P-glycoprotein 12
NO synthase 12
catalase 12
enolase 12
proteasome 12
PARP 11
aldehyde dehydrogenase 11
beta-galactosidase 10
ATPase 10
ACS 10
histidine decarboxylase 10
granzyme B 10
aldehyde dehydrogenase 9
tyrosine hydroxylase 9
aldehyde dehydrogenase 9
aldehyde dehydrogenase 9
MAP 9
aldehyde dehydrogenase 9
collagenase 9
GSK 8
succinate dehydrogenase 8
superoxide dismutase 8
lactate dehydrogenase 8
cathepsin K 7
aspartate aminotransferase 7
renin 7
cdc2 6
carboxypeptidase A 6
MIP 6
phospholipase A2 6
tissue plasminogen activator 6
urokinase-type plasminogen activator 6
NADPH oxidase 6
lysozyme 6
adenylate cyclase 6
PDK1 5
caspase-8 5
topoisomerase 5
TSA 5
calcineurin 5
tyrosine aminotransferase 5
topoisomerase 5
NADPH oxidase 5
elastase 5
choline acetyltransferase 5
guanylate cyclase 5
ribonuclease 4
DNA methyltransferase 4
caspase-9 4
ribonuclease 4
matrix metalloproteinase 9 4
lipase 4
carbonic anhydrase 4
dipeptidyl peptidase IV 4
acid phosphatase 4
phosphoglycerate kinase 4
endonuclease 4
TOR 4
MDR 4
AST 4
CYP3A4 4
ACE 4
glyceraldehyde-3-phosphate dehydrogenase 3
Rex 3
MMP 3
prostate-specific antigen 3
heme oxygenase 3
BMT 3
alanine aminotransferase 3
NADPH-diaphorase 3
alpha-methylacyl-CoA racemase 3
cytosine deaminase 3
TAT 3
glutathione peroxidase 3
gamma-glutamyl transpeptidase 3
TACE 3
indoleamine 2,3-dioxygenase 2
myosin light chain kinase 2
farnesyltransferase 2
PTPase 2
caspase-6 2
farnesyltransferase 2
acrosin 2
dihydrofolate reductase 2
caspase-6 2
firefly luciferase 2
LTC4 synthase 2
AMP-activated protein kinase 2
DTA 2
p100 2
thioredoxin reductase 2
CEP 2
glucose-6-phosphatase 2
isocitrate dehydrogenase 2
phosphodiesterase 2
SMP 2
CEP 2
isocitrate dehydrogenase 2
HSD 2
tryptophan hydroxylase 2
AMPK 2
BAL 2
tryptophan 2,3-dioxygenase 2
GAS 1
adenine phosphoribosyltransferase 1
legumain 1
GRK5 1
diamine oxidase 1
CDR 1
angiotensin-converting enzyme 2 1
choline kinase 1
deaminase 1
caspase-2 1
SCP 1
DNA polymerase 1
methylenetetrahydrofolate reductase 1
inositol 3-kinase 1
MEKK1 1
chymopapain 1
PAL 1
caspase-10 1
CPT 1
RNase T1 1
AMP-activated kinase 1
more...
Compound
tyrosine 517
Dec 485
DNA 387
Clin 224
calcium 87
oxygen 81
ABL 63
TNF 62
BCR 61
ATP 51
retinoic acid 51
Asp 49
serine 46
glucose 45
nitric oxide 41
acetate 40
threonine 38
MEK 38
water 33
Cardiol 33
sodium 32
LTC4 27
methionine 27
arginine 26
lysine 26
Tyrosine 25
phosphate 24
MTT 23
Cbl 21
sulfate 20
Phe 20
Gly 19
His 17
iodine 17
leucine 16
hydrogen 16
formaldehyde 16
tryptophan 16
Hoechst 33342 15
urea 15
zinc 15
Hematoxylin 14
CAM 14
potassium 14
cAMP 14
BAL 14
aspartic acid 14
silver 14
aspartic acid 13
aspartic acid 13
aspartic acid 13
COS 13
DMP 12
DMP 12
DMP 12
cysteine 12
DMP 12
alanine 12
CTX 11
dUTP 11
bromide 11
HPP 10
pyrimidine 10
ACS 10
ACS 10
pyrimidine 10
caffeine 10
PMA 9
iron 9
valine 9
MAP 9
acridine 9
Ara-C 9
TEL 9
Vimentin 8
PGD2 8
DMSO 8
HPC 8
benzene 8
ethanol 8
PMA 8
MDA 8
A 71 8
salt 8
barium 8
HPC 8
quinoline 7
Insulin 7
Wortmannin 7
PAS 7
quinoline 7
TNM 7
Toluidine blue 7
cGMP 7
Ara-C 7
pyridine 7
5-FU 7
tryptophan 7
CMK 7
GSH 6
5-HT 6
hyaluronic acid 6
tryptophan 6
tryptophan 6
CAT 6
W37 6
Ile 6
BUdR 6
GSH 6
Guanine 6
Histamine 6
proline 6
FK506 6
AMP 6
CAT 6
Optimal 6
CAT 6
Hearts 6
PEG 6
nickel 5
EDTA 5
Hearts 5
EDTA 5
quinazoline 5
GAP 5
Rapamycin 5
quinazoline 5
DDP 5
Genistein 5
CPA 5
Adriamycin 5
CPA 5
nicotinamide 5
CPA 5
CPA 5
TEM 5
noradrenaline 5
APS 5
Melanin 5
N-acetylcysteine 4
DAPT 4
isoleucine 4
Phosphatidylinositol 4
glutamate 4
CoA 4
TPA 4
TPA 4
PNA 4
NFS 4
DBA 4
fluorine 4
diacetate 4
NADPH 4
DPG 4
SCC 4
NADPH 4
Rhodamine 123 4
PGE 4
GTP 4
NH2 4
more...