Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P10721 (
c-kit
)
6,575
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
T cells develop through distinct stages directed by a series of signals. We explored the roles of SWI/SNF-like
BAF
chromatin remodeling complexes in this process by progressive deletion of the ATPase subunit, Brg, through successive stages of early T cell development. Brg-deficient cells were blocked at each of the developmental transitions examined. Bcl-xL overexpression suppressed cell death without relieving the developmental blockades, leading to the accumulation of Brg-deleted cells that were unexpectedly cell cycle arrested. These defects resulted partly from the disruptions of pre-TCR and potentially Wnt signaling pathways controlling the expression of genes such as
c-Kit
and c-Myc critical for continued development. Our studies indicate that
BAF
complexes dynamically remodel chromatin to propel sequential developmental transitions in response to external signals.
...
PMID:Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development. 1293 48
