Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P10721 (c-kit)
 6,575 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Chloroma (granulocytic sarcoma or myeloid sarcoma) is a rare malignant extra-medullary neoplasm of myeloid precursor cells. It is usually associated with myeloproliferative disorders but very rarely may precede the onset of leukaemia. Here we are presenting a rare case of chloroma in a female patient without initial presentation of AML. 38 year old female patient, with performance score-1 had complaining of per vaginal bleeding for 1-2 days. Patient consulted gynaecologist and underwent biopsy from anterior fornix of vagina. Biopsy material was positive for LCA (leukocyte common antigen), MPO (myeloperoxidase), c-kit positive on IHC (immunohistocytochemistry) while negative for cytokeratin, synaptophysin, chromogranin, CD20 (cluster of differentiation. Whole body CT scan was non informative except mass lesion at vagina. Patient was given 3+7 induction chemotherapy which was tolerated well followed by high dose cytarabine as consolidation therapy.
 ...
PMID:Primary Vaginal Chloroma: A Rare Case Report. 3059 16