Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P10636 (tau protein)
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Human Gene/Protein
FLJ35024 12.6
tau protein 12.6
FAM178A 12.6
Histone H2A type 1 12.6
tau tubulin kinase 1 12.6
Histone H2B type 1-K 12.6
LRRC37A4 12.6
LRRC37A2 12.6
SYNJ1 protein 12.6
PCDHGB4 12.6
ZNF605 12.6
LRRC37A1 12.6
ZSCAN29 12.6
LOC644246 12.6
Tau-tubulin kinase 12.1
LRRC37A 11.9
ubiquitin carboxy-terminal esterase 11.6
LRRC37B 11.6
NICASTRIN 11.6
Tau-tubulin kinase 1 11.6
transforming growth factor, beta 2 11.6
MGC57346 11.6
ARMCX4 11.6
DC11 11.4
chromatin modifying protein 2B 11.3
ABHD8 11.0
EF-hand calcium-binding domain-containing protein 9 11.0
SPPL2c 11.0
DSCP1 11.0
DnaJA2 11.0
Pre-B-cell leukemia transcription factor 1 11.0
RBMXL1 11.0
DCAKD 11.0
CHMP2B 10.9
SYT11 10.9
ACMSD 10.8
KIAA1267 10.8
STX6 10.7
hDcp1b 10.6
TBC1D16 10.6
ubiquitin specific peptidase 14 10.6
DNAH14 10.6
IMP4 10.6
PPP2R4 10.6
PHYHD1 10.6
BST1 10.6
TTBK1 10.5
DGK-theta 10.3
GRN 10.3
FBXO47 10.3
CSAG2 10.3
ERMP1 10.3
MOBP 10.3
TMEM163 10.2
MCCC1 10.1
UTP14A 10.0
PCN1 10.0
Ephrin type-A receptor 1 10.0
TUBB4 10.0
PGBD1 10.0
MYO5C 10.0
NFASC 10.0
sodium/bile acid cotransporter 10.0
ARHGAP27 10.0
PSEN2 10.0
GAK 9.9
HIP1R 9.9
STK39 9.8
GPR22 9.8
N-myc downstream-regulated gene 3 9.8
DCHS2 9.8
SR-like splicing factor 9.8
PR55 beta 9.8
HIST1H2AL 9.8
CHMP4A 9.8
solute carrier family 6 member 4 9.8
FE65L2 9.8
JAKMIP1 9.8
MARCH-IV 9.8
TMEM175 9.8
splicing factor 9G8 9.8
APH-1B 9.8
TTBK2 9.7
chromosome 9 open reading frame 72 9.7
APBB2 9.7
PSEN1 9.6
brain mitochondrial carrier protein-1 9.6
septin 5 9.6
Kv9.2 9.6
SNCAIP 9.6
PCMTD1 9.6
rod-derived cone viability factor 9.6
CDK5 protein 9.6
netrin G1 9.6
HIST1H2BK 9.6
TAU 9.6
TUBB1 9.5
PHF6 9.5
with Parkinsonism 9.5
C9orf72 9.5
TMEM106B 9.5
TARDBP 9.5
TM2D3 9.4
TFCP2 9.4
MMRN1 9.4
KNS2 9.4
carboxy terminus of HSP70-interacting protein 9.4
HIST2H2BE 9.4
MARCH7 9.4
RAB7L1 9.4
APH1A 9.4
ARL17A 9.4
atrophin 1 9.4
CMPK1 9.4
ABLIM1 9.4
VPS13C 9.4
SNCA 9.4
PHF1 9.4
GIGYF2 9.3
PRKAR1B 9.3
synaptopodin 2 9.3
MDN1 9.3
EIF4G1 9.3
ATPase homolog 9.3
SIPA1L2 9.3
SYNPO 9.3
RASA5 9.3
TRIP10 9.3
Peptidyl-prolyl cis-trans isomerase 9.3
CHCHD10 9.2
FBXO7 9.2
aaa 9.2
Mark2 9.1
CDC-like kinase 2 9.1
MYH13 9.1
SNAP91 9.1
Neuronal protein 9.1
LASS1 9.1
SS18L1 9.1
IGSF10 9.1
MS4A6E 9.1
GRID2IP 9.1
SORL1 9.1
Dual-specificity phosphatase 2 9.0
SCA11 9.0
CAMKK 9.0
Raftlin 9.0
BAG2 9.0
MXRA8 9.0
microtubule associated protein 9.0
MARK2 9.0
DPYSL2 8.9
SYNPO2 8.9
PPP1R9B 8.9
IPP5 8.9
hnRNPA0 8.9
HSD3B7 8.9
casein kinase I delta 8.9
progranulin 8.9
neurofilament light protein 8.8
more...
Disease
Autosomal Recessive Parkinsonism 12.6
Frontal dementia 12.6
Other Alzheimer's disease 11.6
Tauopathies 11.2
CBRS 11.0
Non-fluent aphasia 11.0
Corticobasal degeneration 10.2
Frontotemporal dementia 10.2
Pick's disease 9.9
PARK1 9.2
progressive supranuclear palsy 9.2
FTD-ALS 9.1
FTLD 9.0
Pick's disease with Pick bodies 8.9
DA5 8.8
sCJD 8.4
cerebral degeneration 8.3
CMT4A 8.0
HCA1 7.9
Bielschowsky 7.8
AD2 7.7
FUS 7.7
Autoimmune Diabetes 7.6
Alzheimer's disease 7.6
Cerebrospinal fluid rhinorrhea 7.5
Neurodegenerative Disorders 7.5
familial Alzheimer disease 7.4
Hippocampal sclerosis 7.3
DRD 7.3
Acute encephalopathy 7.2
presenile dementia 7.2
ALS2 7.2
Progressive Aphasia 7.2
PARK2 7.2
Griesinger 7.1
dementia 7.1
EBSS 7.1
parkinsonism 7.0
Semantic dementia 7.0
Dementia with Lewy bodies 7.0
PARK6 6.9
PARK7 6.9
AUTS2 6.9
Calcium deficiency 6.7
Creutzfeldt-Jakob disease 6.7
Postoperative cognitive dysfunction 6.7
CJD 6.7
PSP 6.6
Gerstmann 6.6
motor neuron disease 6.6
familial disorder 6.5
anarthria 6.5
Gulf War Syndrome 6.4
pseudobulbar palsy 6.4
Weingarten 6.4
FCU 6.4
USH1C 6.4
senile dementia 6.4
PARK8 6.3
SCA17 6.3
HCHWA 6.2
progressive bulbar palsy 6.2
Balint's syndrome 6.1
PDC 6.1
Sepsis-associated encephalopathy 6.1
frontal lobe syndrome 6.1
memory impairment 6.0
JMS 6.0
abulia 6.0
brain atrophy 6.0
Microangiopathy 6.0
aphasia 5.9
LGMD2A 5.9
SPG11 5.9
brain disorder 5.8
KRS 5.8
CLN6 5.7
apraxia 5.7
cognitive impairment 5.6
Vascular dementia 5.6
Thorn 5.6
PLAT 5.6
anomia 5.6
cognitive deficit 5.5
DMM 5.5
pineocytoma 5.5
Multiple system atrophy 5.5
early disease onset 5.5
acalculia 5.4
SCA2 5.4
amyotrophic lateral sclerosis 5.4
Economo 5.3
mutism 5.3
Temporal lobe 5.2
FGG 5.2
cognitive disorder 5.2
parasomnia 5.2
neuroblastoma 5.1
echolalia 5.1
global aphasia 5.0
Parkinson's disease 5.0
Binswanger 5.0
Globus 5.0
Lowe 4.9
speech disorder 4.9
pineoblastoma 4.9
primary lateral sclerosis 4.9
Herpes simplex encephalitis 4.9
MSF 4.8
domestic abuse 4.8
MPE 4.8
Traumatic Stress Disorder 4.6
Ellis-van Creveld syndrome 4.6
encephalopathy 4.6
APOA1 4.5
DWI 4.5
CHAC 4.5
disinhibition 4.5
Sanfilippo 4.5
MSA 4.5
memory disorder 4.4
hypophosphatasia 4.4
akinesia 4.3
neuritis 4.3
agnosia 4.2
Huntington's disease 4.2
recurrent prostate cancer 4.2
generalized lipodystrophy 4.2
Down syndrome 4.2
NPC 4.2
DMT1 4.2
Sanfilippo syndrome 4.2
movement disorder 4.2
IBM 4.1
degenerative disease 4.1
CREST 4.1
hyperhomocysteinemia 4.1
CLN2 4.1
SCA1 4.0
leukoencephalopathy 4.0
PNET 4.0
Choroid 4.0
Choroid 4.0
amnesia 4.0
acute alcohol intoxication 4.0
Niemann-Pick 4.0
siderosis 3.9
insane 3.9
plaque 3.9
terminal disease 3.9
RP11 3.9
Pseudotumor cerebri 3.9
spongiform encephalopathy 3.8
CAA 3.8
communication disorder 3.8
DYT1 3.8
amyloidosis 3.8
kuru 3.8
PDD 3.7
dysautonomia 3.7
more...
Symptom
amimia 8.7
memory loss 6.9
Behavioral symptoms 6.2
personality change 5.5
visual hallucination 5.4
myoclonus 5.2
forgetfulness 5.2
bradykinesia 5.1
ACHE 4.7
motor symptom 4.7
metamorphopsia 4.7
apathy 4.3
prostration 4.1
cerebellar ataxia 4.0
Involuntary Movement 3.9
fasciculation 3.9
dystonia 3.8
Spots 3.8
rundown 3.6
Decreased activity 3.5
ataxic gait 3.5
dysarthria 3.3
consciousness disturbance 2.9
ophthalmoplegia 2.9
hypothermia 2.7
hypotonia 2.7
tremor 2.6
chorea 2.6
catatonia 2.5
abnormal gait 2.5
tonic-clonic seizure 2.2
ataxia 2.2
nasal discharge 2.2
paraparesis 2.2
anosmia 2.0
menopausal symptoms 1.9
lethargy 1.7
blurred vision 1.6
insomnia 1.6
acute stress 1.4
stridor 1.4
seizures 1.3
thinning 1.1
collapse 1.1
HSA 1.1
dizziness 0.9
starvation 0.8
vertigo 0.8
hypercapnia 0.7
weakness 0.6
acidity 0.3
shortness of breath 0.3
paresis 0.1
agitation 0.0
spasticity -0.1
functional recovery -0.1
anesthesia -0.3
fatigue -1.1
stigma -1.1
anorexia -1.1
dyspnea -1.2
respiratory distress -1.7
discomfort -1.8
discomfort -2.0
headache -2.2
analgesia -2.2
pain -2.6
diarrhea -3.2
Drug
Tramiprosate 10.0
Hymenialdisine 9.3
Alsterpaullone 9.0
Immune globulin 7.6
Aluminum chloride 6.8
4-Hydroxytamoxifen 6.8
Tolfenamic acid 6.2
PPA 5.4
EPL 5.2
Bexarotene 5.2
Artemether 5.1
Tibolone 5.1
Parkin 4.9
Parkin 4.9
Atomoxetine 4.9
Methylene blue 4.9
Frontal 4.6
Donepezil 4.5
Premarin 4.3
CSF 4.3
K-252a 4.2
Taxol 4.0
Pronase 3.8
Liraglutide 3.8
GEO 3.6
DM1 3.6
Ginseng 3.5
CFT 3.4
Glide 3.3
Kainic acid 3.3
Phosphatidylserine 3.2
IL-1ra 3.2
Tocopherol 3.2
MAP 3.1
Gelfoam 3.1
Pravastatin 2.9
Simvastatin 2.9
DFP 2.7
ROC 2.7
Sodium nitroprusside 2.7
PFA 2.6
Salbutamol 2.6
CTC 2.6
AraC 2.6
NAG 2.5
Paraffin 2.5
MDS 2.5
lysine 2.5
L-tyrosine 2.4
RFP 2.4
Vitamin B12 2.3
Glucagon 2.3
DPA 2.3
CTC 2.3
p75 2.3
NBT 2.2
Lovastatin 2.2
FAD 2.2
Vitamin K 2.2
CTA 2.1
balanced salt solution 2.0
ROS 2.0
Biopolymers 1.9
9-THC 1.9
vitamin E 1.8
Itraconazole 1.7
Check 1.6
Spectrum 1.6
Propofol 1.6
ACT 1.5
DHT 1.5
Estrogens 1.5
DHT 1.4
Fragment 1.4
Ouabain 1.3
Forskolin 1.3
DNase I 1.2
ETA 1.2
CTX 1.1
CTX 1.1
ADM 1.0
Retinoic acid 0.9
MRC 0.9
HCH 0.9
Kenyan 0.8
Leaf 0.8
PCP 0.8
Gel 0.7
Spectrum 0.7
Portal 0.6
ABC 0.5
CTX 0.3
Glutathione 0.2
caffeine 0.2
Histamine 0.2
ascorbate 0.1
CaCl2 -0.0
CaCl2 -0.0
CaCl2 -0.1
Monit -0.5
nitroglycerin -0.5
Ethanol -0.7
citric acid -0.7
Asn -0.9
NADH -1.8
Enzyme
GSK 7.8
CYP46A1 6.7
CLK1 6.7
protein phosphatase 2A 6.6
beta-secretase 6.3
isopeptidase 6.0
neuropsin 6.0
peptidyl-prolyl cis-trans isomerase 5.6
CaMKII 5.4
cdc2 5.4
arachidonate 5-lipoxygenase 5.4
neuropsin 5.3
O-GlcNAc transferase 5.2
Omi/HtrA2 5.2
mu-calpain 5.2
calcineurin 5.1
insulin-degrading enzyme 5.1
AGT 5.0
Thy1 4.9
lambda exonuclease 4.9
enolase 4.7
kinesin 4.6
protein kinase 4.6
caspase-2 4.6
CNPase 4.5
caspase-2 4.5
biliverdin reductase 4.5
phosphorylase kinase 4.4
IKK 4.3
PNL 4.2
MAP 4.1
phospholipid hydroperoxide glutathione peroxidase 4.1
caspase-4 4.1
alanine aminopeptidase 4.1
nicotinamide phosphoribosyltransferase 4.1
choline acetyltransferase 4.1
legumain 4.0
ascorbate oxidase 4.0
m-calpain 3.9
caspase-4 3.9
cathepsin D 3.9
CDR 3.9
chloroperoxidase 3.9
endoproteinase Glu-C 3.9
acetylcholinesterase 3.9
cholinesterase 3.8
STK11 3.7
caspase-6 3.7
proteasome 3.7
glucocerebrosidase 3.7
DAT 3.7
pyruvate dehydrogenase 3.6
pyruvate dehydrogenase 3.6
caspase-6 3.6
CYP27A1 3.5
transglutaminase 3.5
prenyltransferase 3.5
proteinase K 3.4
caspase-3 3.4
AMPK 3.4
MPP 3.3
heparinase 3.3
PGM 3.1
E-2 3.1
CEP 3.1
mitogen-activated protein kinase 3.0
pyruvate dehydrogenase 3.0
TMT 3.0
prolyl endopeptidase 3.0
ubiquitin-protein ligase 3.0
complex I 2.9
cathepsin B 2.9
GRK2 2.8
glyceraldehyde-3-phosphate dehydrogenase 2.8
glyceraldehyde-3-phosphate dehydrogenase 2.8
prolyl hydroxylase 2.8
Pla 2.8
MEKK1 2.7
glyceraldehyde-3-phosphate dehydrogenase 2.7
glyceraldehyde-3-phosphate dehydrogenase 2.7
CD10 2.7
cathepsin L 2.7
phosphatidylinositol 3-kinase 2.6
AMPK 2.6
neuropathy target esterase 2.5
caspase-9 2.5
glyceraldehyde-3-phosphate dehydrogenase 2.5
AMP-activated protein kinase 2.5
alkaline phosphatase 2.5
subtilisin 2.5
CEP 2.5
PDK1 2.5
15-lipoxygenase 2.4
phosphoinositide 3-kinase 2.4
tyrosine hydroxylase 2.3
hypoxanthine-guanine phosphoribosyltransferase 2.3
NADPH-diaphorase 2.3
phosphoglucomutase 2.2
diaphorase 2.2
firefly luciferase 2.2
heme oxygenase 2.2
triphosphatase 2.0
monoamine oxidase 2.0
protein kinase C 2.0
NQO1 2.0
MEK 1.9
aldolase 1.8
tryptophan hydroxylase 1.8
NOS 1.8
TdT 1.7
ACS 1.7
DCF 1.7
cholesterol acyltransferase 1.6
lactate dehydrogenase 1.6
CYP3A4 1.6
NADH dehydrogenase 1.5
glutamate decarboxylase 1.5
chymotrypsin 1.5
ADH 1.5
superoxide dismutase 1.5
gamma-glutamyl transpeptidase 1.5
ACE 1.4
malate dehydrogenase 1.4
ERK 1.4
ATP synthase 1.4
transcriptase 1.4
histidine kinase 1.4
glutamine synthetase 1.3
P-glycoprotein 1.2
phosphodiesterase 1.2
sialidase 1.2
histone acetyltransferase 1.2
phosphorylase 1.1
focal adhesion kinase 1.1
cytochrome oxidase 1.1
diaphorase 1.1
glucose-6-phosphatase 1.0
alcohol dehydrogenase 1.0
caspase-1 1.0
luciferase 1.0
STR 1.0
ricin 1.0
granzyme B 0.9
UDP-glucuronosyltransferase 0.9
PARP 0.9
caspase-8 0.9
hexosaminidase 0.8
CD13 0.8
thymidylate synthase 0.8
PCP 0.7
glutathione S-transferase 0.7
NO synthase 0.7
MMP 0.6
guanylate cyclase 0.6
catalase 0.5
chitinase 0.5
lipoxygenase 0.5
RNA polymerase 0.5
glutathione peroxidase 0.5
topoisomerase 0.4
more...
Compound
5,6-dichloronicotinic acid 11.0
Justicidin A 10.3
2,3-dihydro-1H-cyclopenta[b]quinoline 9.8
2,3-dimethoxyphenol 9.6
Pomiferin 9.4
RD4 9.0
Cycasin 8.9
Thioflavine S 8.2
Glycogen synthase 8.1
Hymenialdisine 8.0
Cocaine hydrochloride 7.6
OLN 7.5
1-methylpiperidine 7.2
Blue Tetrazolium 7.2
Homotaurine 7.1
Orientin 7.1
TDP 7.0
Kyotorphin 6.9
3-Deazaneplanocin 6.9
K19 6.8
Indirubin 6.7
Phosphoserine 6.7
Rutaecarpine 6.7
DX-52-1 6.6
Rutaecarpine 6.6
Azure A 6.5
DVC 6.5
Maneb 6.5
PSP 6.5
Distamycin A 6.4
CHIP 6.2
Isoform 6.2
Ginsenoside Rg1 6.1
Estramustine 6.0
Okadaic acid 6.0
Mercaptopropionic acid 6.0
Selenomethionine 5.8
Calyculin A 5.8
Palmitoylethanolamide 5.8
Juglone 5.7
Harmine 5.7
Memantine 5.7
Galangin 5.6
15(S)-HETE 5.6
Lithium chloride 5.5
Evodiamine 5.5
D-Serine 5.5
Diisopropyl 5.5
Evodiamine 5.4
CBN 5.4
EOC 5.3
Ubiquitin 5.2
Thioflavin T 5.2
PPA 5.2
Nobiletin 5.1
Filipin 5.0
Tauroursodeoxycholic acid 4.9
phosphoserine 4.9
Neuronal 4.8
Acetyl-L-carnitine 4.8
12(S)-HETE 4.8
threonine 4.8
TAR 4.7
Mangiferin 4.7
Cannabidiol 4.7
Congo red 4.7
Telmisartan 4.6
MPE 4.6
Fisetin 4.6
Cinnamaldehyde 4.6
DMM 4.6
3,4-Methylenedioxymethamphetamine 4.5
SSH 4.5
Methylene blue 4.5
APH 4.5
Trimethylamine N-oxide 4.4
9H-carbazole 4.4
Selegiline 4.4
NaAsO2 4.4
L-threonine 4.4
pentosidine 4.3
Tacrine 4.3
Premarin 4.3
Linolenic acid 4.3
Rosmarinic acid 4.3
Rosmarinic acid 4.3
Homocysteine 4.3
perchloric acid 4.3
Homocysteine 4.3
PPA 4.2
Glycogen 4.2
Nocodazole 4.2
galanthamine 4.2
MME 4.2
HPT 4.2
Microcystin-LR 4.1
Dieldrin 4.1
TPCK 4.1
Staurosporine 4.1
proline 4.1
Lithium 4.0
Prone 4.0
Staurosporine 4.0
Riluzole 3.9
4-methoxybenzyl 3.9
Rotenone 3.9
Puerarin 3.9
BAP 3.9
pyridazine 3.9
pyridazine 3.9
serine 3.9
2-naphthyl 3.9
Morin 3.9
2-nonenal 3.9
DDC 3.9
MAP 3.9
DDC 3.8
Colcemid 3.8
Selectin 3.8
TBP 3.8
malononitrile 3.8
DHF 3.8
Crocin 3.7
Adenine 3.7
NBQX 3.7
STZ 3.7
Cortisone 3.7
DRB 3.7
Minocycline 3.7
Naringin 3.7
DAT 3.7
GA1 3.6
AGE 3.6
Antimycin 3.6
Tanshinone 3.6
Isoflurane 3.6
CAA 3.6
MPT 3.6
Colchicine 3.6
Carnosine 3.6
Alum 3.6
ASN 3.6
TBP 3.6
Valine 3.6
Epigallocatechin gallate 3.6
Anthocyanin 3.5
Trehalose 3.5
8-OHdG 3.5
LPR 3.5
Serine 3.5
Wortmannin 3.4
Paclitaxel 3.4
MPP 3.4
Casein 3.4
ACI 3.4
Pravastatin 3.4
MPP 3.4
pinacol 3.4
GlcNAc 3.4
Cytochalasin D 3.3
more...