Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
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Drug
Enzyme
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Target Concepts:
Gene/Protein
Disease
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Query: UNIPROT:P10636 (
tau protein
)
5,110
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Tau-tubulin kinase 2
(
TTBK2
) is a Ser/Thr kinase that putatively phosphorylates residues Ser208 and Ser210 (numbered according to a 441-residue human tau isoform) in
tau protein
. Functional analyses revealed that a recombinant kinase domain (residues 1-331) of human
TTBK2
expressed in insect cells with a baculovirus overexpression system retains kinase activity for
tau protein
. The kinase domain of
TTBK2
was crystallized using the hanging-drop vapour-diffusion method. The crystals belong to space group P2(1)2(1)2(1), with unit-cell parameters a = 55.6, b = 113.7, c = 117.3 A, alpha = beta = gamma = 90.0 degrees. Diffraction data were collected to 2.9 A resolution using synchrotron radiation at BL24XU of SPring-8.
...
PMID:Expression, purification and crystallization of a human tau-tubulin kinase 2 that phosphorylates tau protein. 1762 Jul 22
