Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P10636 (
tau protein
)
5,110
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Alzheimer's disease is associated with the formation of paired helical filaments composed of hyperphospharylated
tau protein
. Phosphatase 2B, calcineurin can dephosphorylate the
tau protein
and, therefore, might prevent the assembly of paired helical filaments and even Alzheimer's disease. Calcipressin 1, the
DSCR1
(Adapt78) gene product, can bind and inactivate calcineurin. Here we hypothesize that while short-term induction of calcipressin1 can provide stress protection, its long-term or chronic induction may cause gradual accumulation of hyperphosphorylated
tau protein
, eventually leading to Alzheimer's disease.
...
PMID:DSCR1(Adapt78)--a Janus gene providing stress protection but causing Alzheimer's disease? 1271 59
