Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P10636 (tau protein)
 5,110 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1. SH-SY5Y, a human neuroblastoma cell line, was used as a tissue culture model to examine the hypothesis that cocaine may affect the metabolism of tau protein which stabilizes microtubules and promotes microtubule assembly. 2. Cocaine hydrochloride (10(-9)-10(-3) M) caused dose-dependent reductions in cell number, with 10(-3) M causing 28% reduction after 48 hr. 3. This drug also decreased tau protein (50 Kd) in the cytoplasmic (supernatant) as well as the membrane (pellet) fraction after 48-hr treatment.
Gen Pharmacol 1992 Nov
PMID:Microtubular tau protein after cocaine in cultured SH-SY5Y human neuroblastoma. 148 20

1. A human neuroblastoma cell line, SH-SY5Y, was used to study the effects of phencyclidine (PCP) on microtubule-associated tau protein, which acts in vivo chiefly to induce the assembly of tubulin and in vitro to promote microtubule polymerization. 2. PCP (1.0 mM) decreased tau protein (50 kD) in the cytoplasmic (supernatant) fraction as well as in the membrane (pellet) fraction. 3. These changes in tau protein were accompanied by decreases of 30-95% in cell number after concentrations of PCP, 0.25-1.0 mM, respectively. 4. After 0.5 mM PCP cytoplasmic and membrane fractions of SH-SY5Y cells showed 100 and 84% increases in total protein, respectively.
Gen Pharmacol 1992 May
PMID:Changes in microtubule-associated tau protein in human neuroblastoma cells after phencyclidine. 151 52

1. SH-SY5Y, an adrenergic human neuroblastoma cell line, was used to examine the hypothesis that D-lysergic acid (LSD) affects the metabolism of microtubule-associated tau protein, thus affecting microtubule assembly and the transport of neurotransmitters. 2. After 48 hr treatment LSD (10(-5) and 10(-7) M) decreased 50 kDa tau protein in the membrane (pellet) fraction. The drug (10(-5) M) also decreased in the cytoplasmic (supernatant) fraction. 3. This reduction in tau protein was accompanied by a 65% increase (P < 0.05) in total protein after LSD (10(-7) M) in the cytoplasmic fraction.
Gen Pharmacol 1995 Sep
PMID:D-lysergic acid reduces microtubule-associated tau protein in SH-SY5Y human neuroblastoma cells. 755 48

1. Cultured human SH-SY5Y neuroblastoma cells were used to determine whether 17-beta-estradiol affects the metabolism of microtubular tau protein. 2. After 24-hr treatment 17-beta-estradiol (10(-7) M) increased 50 kDa tau protein in the cytoplasmic (supernatant) fraction and decreased it in the membrane (pellet) fraction. 3. The increase in cytoplasmic tau was accompanied by increases in total protein in both cytoplasmic and membrane fractions, 50 and 70%, respectively. 4. The estrogen (10(-7) M) also caused a 31% reduction in the total number of cells.
Gen Pharmacol 1993 Nov
PMID:Changes in microtubular tau protein after estrogen in a cultured human neuroblastoma cell line. 790 61

1. A human neuroblastoma cell line, SH-SY5Y, was used to determine the effects of delta-9-tetrahydrocannabinol (THC) on microtubule-associated tau protein. 2. After 48-hr treatment, THC (10(-9) M) decreased 50 kD tau protein in the cytoplasmic (supernatant) fraction, and in the membrane (pellet) fraction the drug (10(-7) M) also decreased 50 kD tau protein. 3. This reduction in tau protein was accompanied by a 27% reduction (P < 0.05) in the membrane (pellet) total protein after (10(-7) M) THC and a 28% increase (P < 0.02) in cytoplasmic (supernatant) total protein after 10(-9) M THC.
Gen Pharmacol 1996 Oct
PMID:Tau protein after delta-9-tetrahydrocannabinol in a human neuroblastoma cell line. 898 Oct 58

1. Cultured human SH-SY5Y adrenergic neuroblastoma cells were used to examine the action of morphine sulfate on microtubular tau protein. 2. After 48 hr treatment morphine sulfate (200 microM) reduced tau protein in the cytoplasmic (supernatant) fraction of undifferentiated cells, and in the cytoplasmic as well as membrane (pellet) fractions of differentiated cells. 3. A 71% increase (P < 0.05) in total protein in the membrane (pellet) fraction of undifferentiated cells and a 188% increase (P < 0.01) in that of differentiated cells accompanied the decrease in tau protein. 4. A 51% reduction (P < 0.01) in the number of undifferentiated (but not differentiated) cells was seen after this drug (200 microM).
Gen Pharmacol 1997 Nov
PMID:Changes in microtubular tau protein after morphine in a cultured human neuroblastoma cell line. 934 40

The Parkinson disease (PD) is the second most common progressive neurodegenerative disorder that arises due to degeneration of dopaminergic neurons. The causes of this disease are still unknown, but a number of genes involved in pathogenesis of familial and sporadic forms of PD has been identified. According to recent data of genome wide association studies (GWAS), single nucleotide polymorphisms (SNPs) in these genes (including MAPT locus) may play an important role in the development of PD. Therefore, we analyzed distribution of genotype frequencies of SNP rs415430 in the WNT3 gene in the Russian patients with sporadic PD and in the Russian population controls (OR = 0.84, Confidence Interval (95% CI) 0.58-1.23, p = 0.39). It was concluded that SNP rs415430 in the WNT3 gene was not associated with the risk of development of PD.
Mol Gen Mikrobiol Virusol 2011
PMID:[Analysis of single nucleotide polymorphism rs415430 in the WNT3 gene in the Russian population with the Parkinson disease]. 2178