Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P10636 (
tau protein
)
5,110
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Abnormal accumulation of
tau protein
into oligomers contributes to neuronal dysfunction. Reduction of tau level is potentially able to prevent its accumulation. Here we uncover a critical role of the free thiol at Cys-322 in determining tau stability. We found that the application of thiol-blocking agents like NEM or MMTS blocks this thiol, by which it destabilizes
tau protein
and prevents its oligomer formation. Furthermore, we identified a tau-interacting protein,
selenoprotein W
, which attenuates tau accumulation by forming disulfide linkage between
SelW
Cys-37 and tau Cys-322. These findings provide a promising strategy to prevent tau accumulation and oligomer formation.
...
PMID:Blocking the Thiol at Cysteine-322 Destabilizes Tau Protein and Prevents Its Oligomer Formation. 2971 59
