Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P10636 (tau protein)
 5,110 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We have previously demonstrated that hippocampal cholinergic neurostimulating peptide (HCNP)-related components accumulate in almost all Hirano bodies in Sommer's sector of the hippocampus of elderly individuals, and that the number of HCNP-positive Hirano bodies is greater in patients with Alzheimer's disease. Although Hirano bodies occur preferentially in the neuronal processes of the stratum pyramidale of the hippocampus, they can be seen occasionally as small inclusions, intermingled with neurofibrillary tangles and in association with senile plaques. Here we show that the small inclusions are also recognized by an anti-HCNP antibody, and by using immunoelectron microscopy demonstrate that these HCNP-positive inclusions, intermingled with tau protein-positive neurofibrillary tangles and beta-amyloid-positive senile plaques are indeed Hirano bodies. These findings strongly suggest that HCNP-related components may be involved in Hirano body formation.
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PMID:Possible implication of hippocampal cholinergic neurostimulating peptide (HCNP)-related components in Hirano body formation. 893 Sep 56

Hippocampal cholinergic neruostimulating peptide (HCNP) induces acethylcholine synthesis in the adult hippocampus of mice via increasing the amount of cholineacethyl transferase. The precursor protein of HCNP (HCNP-pp), composed of 186 amino acids, is a multifunctional protein, such as c-Raf kinase inhibitory protein and phosphatidylethanolamine-binding protein. In the adult hippocampus, HCNP-pp co-localizes in presynapse terminals with non-phosphorylated collapsin response mediator protein (CRMP)-2, and might play a crucial role in hippocampal neuronal activity. The quantitative alteration of HCNP-pp might be related to the phosphorylation of CRMP-2. The expression of HCNP-pp mRNA is decreased in hippocampal pyramidal neurons of CA1 from the early stage in Alzheimer's disease. The HCNP-related antigens are also deposited in the Hirano body, one locus of Alzheimer pathology. CRMP-2 is one of microtubule-associated proteins such as tau protein, and its phosphorylated form increased in the hippocampus of Alzheimer brains. HCNP and HCNP-pp might be candidates for the key molecules as a therapeutic target in Alzheimer's disease.
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PMID:[The involvement of hippocampal cholinergic neurostimulating peptide and its precursor in Alzheimer pathogenesis]. 2507 79