Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P10636 (
tau protein
)
5,110
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Che-1
is a nuclear protein involved in the regulation of gene transcription and cell proliferation. It has also been shown to localize to the cytoplasm of postmitotic neuronal cells, where it is able to interact with the
microtubule-associated protein tau
. Cyclin-dependent kinase 5 (Cdk5) is a postmitotic proline-directed serine/threonine kinase that hyperphosphorylates tau under pathological conditions. We observed that
Che-1
overexpression induces Cdk5 expression both at the mRNA and protein levels. Furthermore, we show that
Che-1
directly interacts with Cdk5 protein in vivo. Cdk5/
Che-1
complex formation does not compete with Cdk5/p35 interaction, thus
Che-1
is able to bind the active kinase complex. Finally, we demonstrated that
Che-1
is itself a Cdk5 substrate.
...
PMID:Che-1 enhances cyclin-dependent kinase 5 expression and interacts with the active kinase-complex. 1838 33
