Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P10415 (Bcl-2)
33,771 document(s) hit in 31,850,051 MEDLINE articles (0.03 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Bcl-2 33771
caspase-3 9955
p53 5050
cytochrome c 3816
caspase-9 3065
Mol 2950
Sep 2199
PARP 1880
caspase-8 1847
Fas 1682
Mcl-1 1552
Bak 1430
p21 1336
bcl-2 1309
anti-apoptotic protein 1285
p38 1220
annexin V 1179
PI3K 1161
TNF 1159
Bid 1062
JNK 1046
superoxide dismutase 997
Bax protein 975
AKT 973
ROS 956
tumor necrosis factor 942
ERK 939
cyclin D1 925
MAPK 906
cytokine 906
endoplasmic reticulum 883
GSH 840
Bcl-X 833
ERK1 759
mTOR 739
survivin 723
IL-6 681
catalase 654
cytochrome 618
pro-apoptotic protein 607
p65 569
poly(ADP-ribose) polymerase 562
ATP 559
proliferating cell nuclear antigen 520
BAX 498
lactate dehydrogenase 497
LC3 495
SOD 494
inducible nitric oxide synthase 486
Ki-67 484
bax 484
XIAP 480
p27 466
c-Jun 459
glutathione peroxidase 453
c-Myc 445
STAT3 432
FasL 410
lymphoid 403
proteasome 392
insulin 391
vascular endothelial growth factor 390
Beclin-1 387
poly (ADP-ribose) polymerase 385
VEGF 380
CD4 380
CD8 366
extracellular signal-regulated kinase 355
CD95 353
inhibitor of apoptosis 352
MMP-9 349
phosphatidylinositol 3-kinase 344
Fas ligand 333
COX-2 330
MEK 316
TRAIL 312
c-myc 309
cyclin 306
Apaf-1 305
catenin 304
more...
Disease
cancer 8564
tumor 5804
breast cancer 1639
leukemia 1309
carcinoma 1226
tumor growth 1162
ischemia 1138
MCF 1038
hepatocellular carcinoma 987
GSH 841
lymphoma 764
prostate cancer 752
tumorigenesis 716
lung cancer 704
B-cell lymphoma 670
carcinogenesis 611
colon cancer 607
melanoma 592
Alzheimer's disease 556
diabetes 551
adenocarcinoma 513
neuroblastoma 494
gastric cancer 487
colorectal cancer 459
Parkinson's disease 444
cerebral ischemia 412
glioma 394
stroke 387
squamous cell carcinoma 378
acute myeloid leukemia 365
tumor progression 358
multiple myeloma 332
ovarian cancer 328
non-small cell lung cancer 325
cervical cancer 318
chronic lymphocytic leukemia 284
myocardial ischemia 271
glioblastoma 262
pancreatic cancer 259
liver cancer 250
osteosarcoma 240
myocardial infarction 224
chronic lymphocytic leukemia 222
metastases 210
heart failure 190
liver cancer 189
lung carcinoma 183
HIV 181
Epstein 180
chronic myeloid leukemia 177
atherosclerosis 176
acute promyelocytic leukemia 172
hyperglycemia 171
Leukemia 166
sepsis 158
sepsis 158
bladder cancer 157
Hodgkin's disease 156
acute lymphoblastic leukemia 154
follicular lymphoma 152
cognitive impairment 150
retinoblastoma 150
DDP 147
virus infection 146
pheochromocytoma 145
renal cell carcinoma 140
hypertension 127
type 2 diabetes 116
non-Hodgkin's lymphoma 112
depression 111
epithelial ovarian cancer 108
obesity 108
AGS 104
Hepatocellular carcinoma 102
Burkitt's lymphoma 101
myeloid leukemia 99
skin cancer 98
immunodeficiency 97
Blocking 95
oral cancer 95
more...
Symptom
collapse 200
starvation 178
seizures 101
functional recovery 86
pain 72
anesthesia 53
hyperoxia 51
hypothermia 45
diarrhea 30
exhaustion 27
splenomegaly 26
memory loss 22
fatigue 18
respiratory distress 18
weakness 17
skin damage 15
abdominal pain 12
thinning 12
nausea 11
cough 11
acute stress 11
bradykinesia 10
tremor 10
ataxia 10
acidity 9
cachexia 9
headache 8
hepatosplenomegaly 8
vomiting 8
Scratch 8
hypercapnia 7
dyspnea 7
chest pain 6
angina 6
constipation 6
dizziness 5
analgesia 5
hepatomegaly 5
exertional dyspnea 4
HSA 4
erythema 4
vertigo 4
menopausal symptoms 3
anorexia 3
loss of balance 3
Anoxia 3
arthralgia 3
discomfort 3
dry eye 3
discomfort 3
POA 3
disturbed balance 3
despair 3
ENT 3
cerebellar ataxia 3
low back pain 2
chronic constipation 2
decreased appetite 2
Organ failure 2
forgetfulness 2
neurological disability 2
shortness of breath 2
Inflammatory pain 2
neurological pain 2
cancer pain 2
pelvic pain 2
sleepiness 2
stigma 2
Wind 2
spasticity 2
insomnia 2
distraction 2
Neuropathic pain 2
incoordination 2
blurred vision 2
spasm 2
chorea 1
stomach pain 1
No adverse effect 1
Decreased activity 1
more...
Drug
ROS 956
IL-2 247
Monit 158
Dermatol 128
BH4 112
MAP 100
IFN-gamma 100
vitamin E 91
Taxol 88
Cardiovasc 79
lysine 74
CED 72
Arsenic trioxide 67
ascorbate 62
Bortezomib 55
CSF 54
Adriamycin 54
ADR 53
Parkin 38
TTC 38
Parkin 38
ICI 38
Glutathione 38
ADM 37
caffeine 37
CTX 36
Ethanol 36
Angiotensin II 36
Genasense 34
VCR 33
Rituximab 33
Docetaxel 33
VCR 33
Glycyrrhiza 32
EE2 29
Sorafenib 29
Etoposide 28
p75 28
Paraffin 28
TAT 26
MRC 26
G-CSF 26
Emodin 25
NADH 25
CAM 25
Imatinib 25
Emodin 25
Mutagen 23
Vitamin E 23
Simvastatin 22
Fluorescein 22
ZnO 21
Propofol 21
Rasagiline 21
Flavopiridol 20
Gefitinib 20
NVP 20
Epigallocatechin 19
CTX 18
ABC 18
CTX 18
PFT 18
Heme 17
Oxaliplatin 16
Estrogens 16
CPT-11 16
Glucagon 16
3-Methyladenine 15
Retinoic acid 15
G418 15
lactose 15
uPA 15
Indomethacin 15
2-Methoxyestradiol 15
CoCl2 14
CoCl2 14
Photofrin 13
ALA 13
DEX 13
Ginger 13
more...
Enzyme
caspase-3 7976
mitogen-activated protein kinase 2944
caspase-9 2524
PARP 2091
caspase-8 1477
superoxide dismutase 1437
ERK 1386
protein kinase 938
catalase 814
lactate dehydrogenase 515
focal adhesion kinase 502
glutathione peroxidase 462
MEK 436
luciferase 414
proteasome 397
protein kinase C 345
phosphatidylinositol 3-kinase 344
cdc2 303
GSK 267
alanine aminotransferase 264
aspartate aminotransferase 255
AMP-activated protein kinase 234
caspase-1 226
peroxidase 197
P-glycoprotein 185
AMPK 167
creatine kinase 163
glutathione S-transferase 158
phosphoinositide 3-kinase 157
AMPK 157
ATPase 154
caspase-7 151
caspase-7 148
CD10 147
calcineurin 145
reverse transcriptase 132
tyrosine hydroxylase 118
MMP 118
TdT 114
caspase-2 112
AST 111
caspase-2 107
NADPH oxidase 106
IKK 104
MPP 103
glutathione reductase 102
topoisomerase 101
topoisomerase 99
NADPH oxidase 96
alkaline phosphatase 92
MAP 83
complex I 74
collagenase 72
acetylcholinesterase 71
NO synthase 70
ACS 68
granzyme B 66
NQO1 63
heme oxygenase 59
monoamine oxidase 55
caspase-6 55
NOS 54
Omi/HtrA2 53
cathepsin B 51
caspase-6 51
PDK1 47
APC 45
RNase 45
RNA polymerase 45
RNase 45
MDR 44
protein phosphatase 2A 40
succinate dehydrogenase 40
endonuclease 35
renin 34
phosphodiesterase 33
phospholipase C 33
xanthine oxidase 33
prostate-specific antigen 32
phospholipase A2 32
more...
Compound
DNA 4861
oxygen 3726
Dec 2464
MTT 1952
boron 1305
TNF 1159
glucose 986
MDA 942
calcium 938
GSH 860
GSH 860
Clin 800
water 745
dUTP 720
nitric oxide 594
iodine 570
bromide 563
ATP 559
cysteine 549
hydrogen 496
sodium 410
ADP-ribose 370
N-acetylcysteine 368
serine 320
H2O2 313
MEK 306
tyrosine 296
glutamate 289
ethanol 252
DDP 240
ADP 230
Curcumin 224
alanine 215
Asp 211
ADP 210
ADP 210
Cyt 210
acetate 204
nitrogen 199
creatinine 196
retinoic acid 194
acridine 191
urea 191
phosphate 185
ADR 174
Adriamycin 172
galactose 172
cAMP 169
CAT 166
CAT 166
CAT 166
threonine 163
zinc 151
Hoechst 33342 150
arginine 137
Neuronal 136
cadmium 131
PEG 126
iron 125
Cytochrome c 124
Panam 118
NH2 117
copper 111
Resveratrol 110
selenium 105
diacetate 104
Melatonin 104
5-FU 104
MPP 103
MPP 103
lysine 101
ethyl acetate 100
potassium 100
Pac 98
MPTP 95
AMP 95
Quercetin 95
THP 93
THP 93
Cardiol 88
more...