Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P10415 (
Bcl-2
)
33,771
document(s) hit in 31,850,051 MEDLINE articles (0.03 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
Bcl-2
33771
caspase-3
9955
p53
5050
cytochrome c
3816
caspase-9
3065
Mol
2950
Sep
2199
PARP
1880
caspase-8
1847
Fas
1682
Mcl-1
1552
Bak
1430
p21
1336
bcl-2
1309
anti-apoptotic protein
1285
p38
1220
annexin V
1179
PI3K
1161
TNF
1159
Bid
1062
JNK
1046
superoxide dismutase
997
Bax protein
975
AKT
973
ROS
956
tumor necrosis factor
942
ERK
939
cyclin D1
925
MAPK
906
cytokine
906
endoplasmic reticulum
883
GSH
840
Bcl-X
833
ERK1
759
mTOR
739
survivin
723
IL-6
681
catalase
654
cytochrome
618
pro-apoptotic protein
607
p65
569
poly(ADP-ribose) polymerase
562
ATP
559
proliferating cell nuclear antigen
520
BAX
498
lactate dehydrogenase
497
LC3
495
SOD
494
inducible nitric oxide synthase
486
Ki-67
484
bax
484
XIAP
480
p27
466
c-Jun
459
glutathione peroxidase
453
c-Myc
445
STAT3
432
FasL
410
lymphoid
403
proteasome
392
insulin
391
vascular endothelial growth factor
390
Beclin-1
387
poly (ADP-ribose) polymerase
385
VEGF
380
CD4
380
CD8
366
extracellular signal-regulated kinase
355
CD95
353
inhibitor of apoptosis
352
MMP-9
349
phosphatidylinositol 3-kinase
344
Fas ligand
333
COX-2
330
MEK
316
TRAIL
312
c-myc
309
cyclin
306
Apaf-1
305
catenin
304
more...
Disease
cancer
8564
tumor
5804
breast cancer
1639
leukemia
1309
carcinoma
1226
tumor growth
1162
ischemia
1138
MCF
1038
hepatocellular carcinoma
987
GSH
841
lymphoma
764
prostate cancer
752
tumorigenesis
716
lung cancer
704
B-cell lymphoma
670
carcinogenesis
611
colon cancer
607
melanoma
592
Alzheimer's disease
556
diabetes
551
adenocarcinoma
513
neuroblastoma
494
gastric cancer
487
colorectal cancer
459
Parkinson's disease
444
cerebral ischemia
412
glioma
394
stroke
387
squamous cell carcinoma
378
acute myeloid leukemia
365
tumor progression
358
multiple myeloma
332
ovarian cancer
328
non-small cell lung cancer
325
cervical cancer
318
chronic lymphocytic leukemia
284
myocardial ischemia
271
glioblastoma
262
pancreatic cancer
259
liver cancer
250
osteosarcoma
240
myocardial infarction
224
chronic lymphocytic leukemia
222
metastases
210
heart failure
190
liver cancer
189
lung carcinoma
183
HIV
181
Epstein
180
chronic myeloid leukemia
177
atherosclerosis
176
acute promyelocytic leukemia
172
hyperglycemia
171
Leukemia
166
sepsis
158
sepsis
158
bladder cancer
157
Hodgkin's disease
156
acute lymphoblastic leukemia
154
follicular lymphoma
152
cognitive impairment
150
retinoblastoma
150
DDP
147
virus infection
146
pheochromocytoma
145
renal cell carcinoma
140
hypertension
127
type 2 diabetes
116
non-Hodgkin's lymphoma
112
depression
111
epithelial ovarian cancer
108
obesity
108
AGS
104
Hepatocellular carcinoma
102
Burkitt's lymphoma
101
myeloid leukemia
99
skin cancer
98
immunodeficiency
97
Blocking
95
oral cancer
95
more...
Symptom
collapse
200
starvation
178
seizures
101
functional recovery
86
pain
72
anesthesia
53
hyperoxia
51
hypothermia
45
diarrhea
30
exhaustion
27
splenomegaly
26
memory loss
22
fatigue
18
respiratory distress
18
weakness
17
skin damage
15
abdominal pain
12
thinning
12
nausea
11
cough
11
acute stress
11
bradykinesia
10
tremor
10
ataxia
10
acidity
9
cachexia
9
headache
8
hepatosplenomegaly
8
vomiting
8
Scratch
8
hypercapnia
7
dyspnea
7
chest pain
6
angina
6
constipation
6
dizziness
5
analgesia
5
hepatomegaly
5
exertional dyspnea
4
HSA
4
erythema
4
vertigo
4
menopausal symptoms
3
anorexia
3
loss of balance
3
Anoxia
3
arthralgia
3
discomfort
3
dry eye
3
discomfort
3
POA
3
disturbed balance
3
despair
3
ENT
3
cerebellar ataxia
3
low back pain
2
chronic constipation
2
decreased appetite
2
Organ failure
2
forgetfulness
2
neurological disability
2
shortness of breath
2
Inflammatory pain
2
neurological pain
2
cancer pain
2
pelvic pain
2
sleepiness
2
stigma
2
Wind
2
spasticity
2
insomnia
2
distraction
2
Neuropathic pain
2
incoordination
2
blurred vision
2
spasm
2
chorea
1
stomach pain
1
No adverse effect
1
Decreased activity
1
more...
Drug
ROS
956
IL-2
247
Monit
158
Dermatol
128
BH4
112
MAP
100
IFN-gamma
100
vitamin E
91
Taxol
88
Cardiovasc
79
lysine
74
CED
72
Arsenic trioxide
67
ascorbate
62
Bortezomib
55
CSF
54
Adriamycin
54
ADR
53
Parkin
38
TTC
38
Parkin
38
ICI
38
Glutathione
38
ADM
37
caffeine
37
CTX
36
Ethanol
36
Angiotensin II
36
Genasense
34
VCR
33
Rituximab
33
Docetaxel
33
VCR
33
Glycyrrhiza
32
EE2
29
Sorafenib
29
Etoposide
28
p75
28
Paraffin
28
TAT
26
MRC
26
G-CSF
26
Emodin
25
NADH
25
CAM
25
Imatinib
25
Emodin
25
Mutagen
23
Vitamin E
23
Simvastatin
22
Fluorescein
22
ZnO
21
Propofol
21
Rasagiline
21
Flavopiridol
20
Gefitinib
20
NVP
20
Epigallocatechin
19
CTX
18
ABC
18
CTX
18
PFT
18
Heme
17
Oxaliplatin
16
Estrogens
16
CPT-11
16
Glucagon
16
3-Methyladenine
15
Retinoic acid
15
G418
15
lactose
15
uPA
15
Indomethacin
15
2-Methoxyestradiol
15
CoCl2
14
CoCl2
14
Photofrin
13
ALA
13
DEX
13
Ginger
13
more...
Enzyme
caspase-3
7976
mitogen-activated protein kinase
2944
caspase-9
2524
PARP
2091
caspase-8
1477
superoxide dismutase
1437
ERK
1386
protein kinase
938
catalase
814
lactate dehydrogenase
515
focal adhesion kinase
502
glutathione peroxidase
462
MEK
436
luciferase
414
proteasome
397
protein kinase C
345
phosphatidylinositol 3-kinase
344
cdc2
303
GSK
267
alanine aminotransferase
264
aspartate aminotransferase
255
AMP-activated protein kinase
234
caspase-1
226
peroxidase
197
P-glycoprotein
185
AMPK
167
creatine kinase
163
glutathione S-transferase
158
phosphoinositide 3-kinase
157
AMPK
157
ATPase
154
caspase-7
151
caspase-7
148
CD10
147
calcineurin
145
reverse transcriptase
132
tyrosine hydroxylase
118
MMP
118
TdT
114
caspase-2
112
AST
111
caspase-2
107
NADPH oxidase
106
IKK
104
MPP
103
glutathione reductase
102
topoisomerase
101
topoisomerase
99
NADPH oxidase
96
alkaline phosphatase
92
MAP
83
complex I
74
collagenase
72
acetylcholinesterase
71
NO synthase
70
ACS
68
granzyme B
66
NQO1
63
heme oxygenase
59
monoamine oxidase
55
caspase-6
55
NOS
54
Omi/HtrA2
53
cathepsin B
51
caspase-6
51
PDK1
47
APC
45
RNase
45
RNA polymerase
45
RNase
45
MDR
44
protein phosphatase 2A
40
succinate dehydrogenase
40
endonuclease
35
renin
34
phosphodiesterase
33
phospholipase C
33
xanthine oxidase
33
prostate-specific antigen
32
phospholipase A2
32
more...
Compound
DNA
4861
oxygen
3726
Dec
2464
MTT
1952
boron
1305
TNF
1159
glucose
986
MDA
942
calcium
938
GSH
860
GSH
860
Clin
800
water
745
dUTP
720
nitric oxide
594
iodine
570
bromide
563
ATP
559
cysteine
549
hydrogen
496
sodium
410
ADP-ribose
370
N-acetylcysteine
368
serine
320
H2O2
313
MEK
306
tyrosine
296
glutamate
289
ethanol
252
DDP
240
ADP
230
Curcumin
224
alanine
215
Asp
211
ADP
210
ADP
210
Cyt
210
acetate
204
nitrogen
199
creatinine
196
retinoic acid
194
acridine
191
urea
191
phosphate
185
ADR
174
Adriamycin
172
galactose
172
cAMP
169
CAT
166
CAT
166
CAT
166
threonine
163
zinc
151
Hoechst 33342
150
arginine
137
Neuronal
136
cadmium
131
PEG
126
iron
125
Cytochrome c
124
Panam
118
NH2
117
copper
111
Resveratrol
110
selenium
105
diacetate
104
Melatonin
104
5-FU
104
MPP
103
MPP
103
lysine
101
ethyl acetate
100
potassium
100
Pac
98
MPTP
95
AMP
95
Quercetin
95
THP
93
THP
93
Cardiol
88
more...