Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P10415 (
Bcl-2
)
33,771
document(s) hit in 31,850,051 MEDLINE articles (0.04 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
Bcl-2
33771
caspase-3
9955
p53
5050
cytochrome c
3816
caspase-9
3065
Mol
2950
Sep
2199
PARP
1880
caspase-8
1847
Fas
1682
Mcl-1
1552
Bak
1430
p21
1336
bcl-2
1309
anti-apoptotic protein
1285
p38
1220
annexin V
1179
PI3K
1161
TNF
1159
Bid
1062
JNK
1046
superoxide dismutase
997
Bax protein
975
AKT
973
ROS
956
tumor necrosis factor
942
ERK
939
cyclin D1
925
MAPK
906
cytokine
906
endoplasmic reticulum
883
GSH
840
Bcl-X
833
ERK1
759
mTOR
739
survivin
723
IL-6
681
catalase
654
cytochrome
618
pro-apoptotic protein
607
more...
Disease
cancer
8564
tumor
5804
breast cancer
1639
leukemia
1309
carcinoma
1226
tumor growth
1162
ischemia
1138
MCF
1038
hepatocellular carcinoma
987
GSH
841
lymphoma
764
prostate cancer
752
tumorigenesis
716
lung cancer
704
B-cell lymphoma
670
carcinogenesis
611
colon cancer
607
melanoma
592
Alzheimer's disease
556
diabetes
551
adenocarcinoma
513
neuroblastoma
494
gastric cancer
487
colorectal cancer
459
Parkinson's disease
444
cerebral ischemia
412
glioma
394
stroke
387
squamous cell carcinoma
378
acute myeloid leukemia
365
tumor progression
358
multiple myeloma
332
ovarian cancer
328
non-small cell lung cancer
325
cervical cancer
318
chronic lymphocytic leukemia
284
myocardial ischemia
271
glioblastoma
262
pancreatic cancer
259
liver cancer
250
more...
Symptom
collapse
200
starvation
178
seizures
101
functional recovery
86
pain
72
anesthesia
53
hyperoxia
51
hypothermia
45
diarrhea
30
exhaustion
27
splenomegaly
26
memory loss
22
fatigue
18
respiratory distress
18
weakness
17
skin damage
15
thinning
12
abdominal pain
12
cough
11
nausea
11
acute stress
11
ataxia
10
tremor
10
bradykinesia
10
cachexia
9
acidity
9
headache
8
vomiting
8
hepatosplenomegaly
8
Scratch
8
hypercapnia
7
dyspnea
7
angina
6
constipation
6
chest pain
6
dizziness
5
hepatomegaly
5
analgesia
5
exertional dyspnea
4
vertigo
4
more...
Drug
ROS
956
IL-2
247
Monit
158
Dermatol
128
BH4
112
MAP
100
IFN-gamma
100
vitamin E
91
Taxol
88
Cardiovasc
79
lysine
74
CED
72
Arsenic trioxide
67
ascorbate
62
Bortezomib
55
CSF
54
Adriamycin
54
ADR
53
Glutathione
38
TTC
38
Parkin
38
ICI
38
Parkin
38
caffeine
37
ADM
37
Ethanol
36
Angiotensin II
36
CTX
36
Genasense
34
VCR
33
Docetaxel
33
Rituximab
33
VCR
33
Glycyrrhiza
32
Sorafenib
29
EE2
29
Paraffin
28
Etoposide
28
p75
28
MRC
26
more...
Enzyme
caspase-3
7976
mitogen-activated protein kinase
2944
caspase-9
2524
PARP
2091
caspase-8
1477
superoxide dismutase
1437
ERK
1386
protein kinase
938
catalase
814
lactate dehydrogenase
515
focal adhesion kinase
502
glutathione peroxidase
462
MEK
436
luciferase
414
proteasome
397
protein kinase C
345
phosphatidylinositol 3-kinase
344
cdc2
303
GSK
267
alanine aminotransferase
264
aspartate aminotransferase
255
AMP-activated protein kinase
234
caspase-1
226
peroxidase
197
P-glycoprotein
185
AMPK
167
creatine kinase
163
glutathione S-transferase
158
phosphoinositide 3-kinase
157
AMPK
157
ATPase
154
caspase-7
151
caspase-7
148
CD10
147
calcineurin
145
reverse transcriptase
132
tyrosine hydroxylase
118
MMP
118
TdT
114
caspase-2
112
more...
Compound
DNA
4861
oxygen
3726
Dec
2464
MTT
1952
boron
1305
TNF
1159
glucose
986
MDA
942
calcium
938
GSH
860
GSH
860
Clin
800
water
745
dUTP
720
nitric oxide
594
iodine
570
bromide
563
ATP
559
cysteine
549
hydrogen
496
sodium
410
ADP-ribose
370
N-acetylcysteine
368
serine
320
H2O2
313
MEK
306
tyrosine
296
glutamate
289
ethanol
252
DDP
240
ADP
230
Curcumin
224
alanine
215
Asp
211
Cyt
210
ADP
210
ADP
210
acetate
204
nitrogen
199
creatinine
196
more...