Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P10415 (Bcl-2)
 33,771 document(s) hit in 31,850,051 MEDLINE articles (0.03 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Bcl-2 33771
caspase-3 9955
p53 5050
cytochrome c 3816
caspase-9 3065
Mol 2950
Sep 2199
PARP 1880
caspase-8 1847
Fas 1682
Mcl-1 1552
Bak 1430
p21 1336
bcl-2 1309
anti-apoptotic protein 1285
p38 1220
annexin V 1179
PI3K 1161
TNF 1159
Bid 1062
JNK 1046
superoxide dismutase 997
Bax protein 975
AKT 973
ROS 956
tumor necrosis factor 942
ERK 939
cyclin D1 925
cytokine 906
MAPK 906
endoplasmic reticulum 883
GSH 840
Bcl-X 833
ERK1 759
mTOR 739
survivin 723
IL-6 681
catalase 654
cytochrome 618
pro-apoptotic protein 607
p65 569
poly(ADP-ribose) polymerase 562
ATP 559
proliferating cell nuclear antigen 520
BAX 498
lactate dehydrogenase 497
LC3 495
SOD 494
inducible nitric oxide synthase 486
bax 484
Ki-67 484
XIAP 480
p27 466
c-Jun 459
glutathione peroxidase 453
c-Myc 445
STAT3 432
FasL 410
lymphoid 403
proteasome 392
insulin 391
vascular endothelial growth factor 390
Beclin-1 387
poly (ADP-ribose) polymerase 385
VEGF 380
CD4 380
CD8 366
extracellular signal-regulated kinase 355
CD95 353
inhibitor of apoptosis 352
MMP-9 349
phosphatidylinositol 3-kinase 344
Fas ligand 333
COX-2 330
MEK 316
TRAIL 312
c-myc 309
cyclin 306
Apaf-1 305
catenin 304
estrogen receptor 302
apoptosis-inducing factor 300
Nrf2 297
PC-3 296
cyclin B1 292
collagen 290
CHOP 289
kit 285
brain-derived neurotrophic factor 280
lipopolysaccharide 277
TNF-alpha 276
LDH 275
cyclooxygenase-2 270
CCK 268
cyclin E 265
CD34 261
Smac 260
mitogen-activated protein 258
GSK 254
protein kinase B 247
IL-2 246
AIF 244
interleukin-6 243
tyrosine kinase 240
proto-oncogene 238
IL-10 234
matrix metalloproteinase 233
E-cadherin 233
p62 229
osteosarcoma 227
heme oxygenase-1 227
MMP-2 224
Bcl-w 223
ubiquitin 223
CDK4 221
PARP-1 220
IFN 217
interacting protein 216
NMR 213
cyclin A 212
ADP 210
outer mitochondrial membrane 208
HO-1 205
GRP78 204
PTEN 202
histone deacetylase 199
epidermal growth factor receptor 199
BAD 194
FADD 191
Cyclin D1 190
TdT 190
histone 188
P-glycoprotein 183
CDK2 183
EGFR 181
PUMA 180
thymus 180
HSP70 178
p38 mitogen-activated protein kinase 178
DR5 177
survival factor 177
erythroid 175
DIABLO 173
CA1 173
CREB 173
vimentin 172
E1B 172
Bfl-1 169
calpain 168
signal transducer and activator of transcription 3 167
CAT 166
proteasome inhibitor 164
cyclin-dependent kinase 162
antioxidant enzyme 157
phosphoinositide 3-kinase 157
phosphatase 156
AMPK 156
CD20 153
glial fibrillary acidic protein 153
interferon 150
more...
Disease
cancer 8564
tumor 5804
breast cancer 1639
leukemia 1309
carcinoma 1226
tumor growth 1162
ischemia 1138
MCF 1038
hepatocellular carcinoma 987
GSH 841
lymphoma 764
prostate cancer 752
tumorigenesis 716
lung cancer 704
B-cell lymphoma 670
carcinogenesis 611
colon cancer 607
melanoma 592
Alzheimer's disease 556
diabetes 551
adenocarcinoma 513
neuroblastoma 494
gastric cancer 487
colorectal cancer 459
Parkinson's disease 444
cerebral ischemia 412
glioma 394
stroke 387
squamous cell carcinoma 378
acute myeloid leukemia 365
tumor progression 358
multiple myeloma 332
ovarian cancer 328
non-small cell lung cancer 325
cervical cancer 318
chronic lymphocytic leukemia 284
myocardial ischemia 271
glioblastoma 262
pancreatic cancer 259
liver cancer 250
osteosarcoma 240
myocardial infarction 224
chronic lymphocytic leukemia 222
metastases 210
heart failure 190
liver cancer 189
lung carcinoma 183
HIV 181
Epstein 180
chronic myeloid leukemia 177
atherosclerosis 176
acute promyelocytic leukemia 172
hyperglycemia 171
Leukemia 166
sepsis 158
sepsis 158
bladder cancer 157
Hodgkin's disease 156
acute lymphoblastic leukemia 154
follicular lymphoma 152
retinoblastoma 150
cognitive impairment 150
DDP 147
virus infection 146
pheochromocytoma 145
renal cell carcinoma 140
hypertension 127
type 2 diabetes 116
non-Hodgkin's lymphoma 112
depression 111
epithelial ovarian cancer 108
obesity 108
AGS 104
Hepatocellular carcinoma 102
Burkitt's lymphoma 101
myeloid leukemia 99
skin cancer 98
immunodeficiency 97
oral cancer 95
Blocking 95
dementia 93
B-cell lymphomas 92
rheumatoid arthritis 92
suicide 92
cardiovascular disease 90
SCID 90
solid tumor 89
brain tumor 89
brain edema 87
ATM 87
dysplasia 84
infectious diseases 84
glioblastoma multiforme 83
esophageal cancer 82
memory impairment 82
Melanoma 79
multiple sclerosis 79
esophageal cancer 77
B-cell chronic lymphocytic leukemia 77
cold 77
mantle cell lymphoma 77
AIDS 76
primary tumor 76
liver fibrosis 75
systemic lupus erythematosus 75
aggressiveness 74
epilepsy 74
tumor angiogenesis 74
diabetic nephropathy 73
CEM 73
amyotrophic lateral sclerosis 72
acute myocardial infarction 72
MTS 71
endometrial cancer 70
cardiomyopathy 69
small cell lung cancer 67
colitis 66
osteoarthritis 66
cytomegalovirus 65
FAS 64
sarcoma 63
plaque 63
vaccinia 63
cerebral infarction 63
autoimmune disease 61
arthritis 60
Infection 60
anemia 59
renal disease 59
Huntington's disease 57
asthma 57
osteoporosis 57
hematologic malignancies 57
subarachnoid hemorrhage 56
herpes simplex 56
hepatitis 56
adenoma 55
Kaposi's sarcoma 54
Pineal 53
renal cancer 51
Osteosarcoma 50
Osteosarcoma 50
renal ischemia 50
liver disease 50
tuberculosis 48
uterus 48
type 1 diabetes 48
Glioblastoma 48
metastatic melanoma 47
Neuroblastoma 45
acute leukemia 45
Neuroblastoma 45
fatty liver 44
NAME 44
diabetic cardiomyopathy 44
HCC 43
TEM 43
mammary tumor 42
Mycobacterium 42
EMA 42
more...
Symptom
collapse 200
starvation 178
seizures 101
functional recovery 86
pain 72
anesthesia 53
hyperoxia 51
hypothermia 45
diarrhea 30
exhaustion 27
splenomegaly 26
memory loss 22
fatigue 18
respiratory distress 18
weakness 17
skin damage 15
thinning 12
abdominal pain 12
nausea 11
acute stress 11
cough 11
ataxia 10
bradykinesia 10
tremor 10
acidity 9
cachexia 9
Scratch 8
headache 8
vomiting 8
hepatosplenomegaly 8
dyspnea 7
hypercapnia 7
constipation 6
angina 6
chest pain 6
dizziness 5
hepatomegaly 5
analgesia 5
exertional dyspnea 4
HSA 4
erythema 4
vertigo 4
anorexia 3
loss of balance 3
Anoxia 3
despair 3
arthralgia 3
disturbed balance 3
dry eye 3
POA 3
discomfort 3
discomfort 3
ENT 3
menopausal symptoms 3
cerebellar ataxia 3
shortness of breath 2
chronic constipation 2
neurological disability 2
neurological pain 2
pelvic pain 2
sleepiness 2
blurred vision 2
spasticity 2
insomnia 2
Wind 2
distraction 2
stigma 2
Neuropathic pain 2
incoordination 2
cancer pain 2
forgetfulness 2
decreased appetite 2
spasm 2
Organ failure 2
low back pain 2
Inflammatory pain 2
muscle cramps 1
chorea 1
stomach pain 1
No adverse effect 1
Decreased activity 1
numbness 1
pallor 1
lassitude 1
paresthesia 1
chronic cough 1
cyanosis 1
ophthalmoplegia 1
anosmia 1
DNA marker 1
motor symptom 1
hyperemesis 1
dental pain 1
torticollis 1
Ill 1
intention tremor 1
loss of equilibrium 1
Acute urinary retention 1
Spinal cord edema 1
upset stomach 1
nausea and vomiting 1
asthenia 1
abnormal gait 1
flank pain 1
halitosis 1
heartburn 1
Motor dysfunction 1
back pain 1
chest tightness 1
twitching 1
Ataxic 1
hot flashes 1
overweight 1
microbial colonization 1
autodigestion 1
Deafferentation 1
Neurologic symptoms 1
hypocapnia 1
bone pain 1
hot flushes 1
chills 1
urinary frequency 1
abdominal discomfort 1
muscle rigidity 1
myoclonus 1
night sweats 1
paraparesis 1
epigastric pain 1
Drug
ROS 956
IL-2 247
Monit 158
Dermatol 128
BH4 112
IFN-gamma 100
MAP 100
vitamin E 91
Taxol 88
Cardiovasc 79
lysine 74
CED 72
Arsenic trioxide 67
ascorbate 62
Bortezomib 55
CSF 54
Adriamycin 54
ADR 53
ICI 38
Glutathione 38
TTC 38
Parkin 38
Parkin 38
ADM 37
caffeine 37
CTX 36
Ethanol 36
Angiotensin II 36
Genasense 34
VCR 33
VCR 33
Rituximab 33
Docetaxel 33
Glycyrrhiza 32
Sorafenib 29
EE2 29
Etoposide 28
p75 28
Paraffin 28
MRC 26
G-CSF 26
TAT 26
Emodin 25
NADH 25
CAM 25
Emodin 25
Imatinib 25
Mutagen 23
Vitamin E 23
Simvastatin 22
Fluorescein 22
Propofol 21
ZnO 21
Rasagiline 21
Flavopiridol 20
Gefitinib 20
NVP 20
Epigallocatechin 19
CTX 18
PFT 18
ABC 18
CTX 18
Heme 17
CPT-11 16
Oxaliplatin 16
Glucagon 16
Estrogens 16
2-Methoxyestradiol 15
G418 15
3-Methyladenine 15
Retinoic acid 15
lactose 15
uPA 15
Indomethacin 15
CoCl2 14
CoCl2 14
Ginger 13
DEX 13
ALA 13
Photofrin 13
Nitric Oxide 13
Propidium 12
Gel 12
AMC 12
Gleevec 12
Rosiglitazone 12
Herceptin 12
Ginseng 12
IL-11 11
Lovastatin 10
-deoxyadenosine 10
Portal 10
DNase I 10
Rutin 10
Itraconazole 10
Taxotere 10
Fludarabine 10
Gelatin 10
Myricetin 10
GEO 9
Ouabain 9
Leaf 9
MDM 9
Ulinastatin 9
Liraglutide 8
Vorinostat 8
AraC 8
NBT 8
CCL 8
Cilostazol 8
Lenalidomide 8
TiO2 7
IFN-beta 7
Imiquimod 7
DHT 7
DHT 7
Bifidobacterium 6
Phosphatidylserine 6
Vinorelbine 6
EPA 6
Dasatinib 6
CIA 6
Cantor 6
Artesunate 6
Forskolin 6
Asn 5
BLyS 5
Swainsonine 5
Activin 5
Vitamin A 5
Sodium nitroprusside 5
Silica 5
Auranofin 5
citric acid 5
Spectrum 5
Azilect 5
Finasteride 5
Zebularine 5
Amiloride 5
Orphan 5
niacin 5
ROC 5
nitroglycerin 5
Fluorescein 5
Asthma 5
Limonene 5
PTC 5
ETS 5
Red ginseng 5
Zoledronic acid 5
Theophylline 5
Triclosan 5
Erlotinib 5
Pravastatin 5
TAC 4
Vitamin K2 4
Albumin 4
Ddc 4
Everolimus 4
Pramipexole 4
more...
Enzyme
caspase-3 7976
mitogen-activated protein kinase 2944
caspase-9 2524
PARP 2091
caspase-8 1477
superoxide dismutase 1437
ERK 1386
protein kinase 938
catalase 814
lactate dehydrogenase 515
focal adhesion kinase 502
glutathione peroxidase 462
MEK 436
luciferase 414
proteasome 397
protein kinase C 345
phosphatidylinositol 3-kinase 344
cdc2 303
GSK 267
alanine aminotransferase 264
aspartate aminotransferase 255
AMP-activated protein kinase 234
caspase-1 226
peroxidase 197
P-glycoprotein 185
AMPK 167
creatine kinase 163
glutathione S-transferase 158
AMPK 157
phosphoinositide 3-kinase 157
ATPase 154
caspase-7 151
caspase-7 148
CD10 147
calcineurin 145
reverse transcriptase 132
tyrosine hydroxylase 118
MMP 118
TdT 114
caspase-2 112
AST 111
caspase-2 107
NADPH oxidase 106
IKK 104
MPP 103
glutathione reductase 102
topoisomerase 101
topoisomerase 99
NADPH oxidase 96
alkaline phosphatase 92
MAP 83
complex I 74
collagenase 72
acetylcholinesterase 71
NO synthase 70
ACS 68
granzyme B 66
NQO1 63
heme oxygenase 59
monoamine oxidase 55
caspase-6 55
NOS 54
Omi/HtrA2 53
caspase-6 51
cathepsin B 51
PDK1 47
RNase 45
APC 45
RNase 45
RNA polymerase 45
MDR 44
protein phosphatase 2A 40
succinate dehydrogenase 40
endonuclease 35
renin 34
phosphodiesterase 33
phospholipase C 33
xanthine oxidase 33
hexokinase 32
phospholipase A2 32
prostate-specific antigen 32
urokinase-type plasminogen activator 31
glyceraldehyde-3-phosphate dehydrogenase 31
trypsin 30
cathepsin D 30
caspase-4 29
ornithine decarboxylase 28
CaMKII 28
beta-galactosidase 28
DNA methyltransferase 27
caspase-4 27
transcriptase 27
ATP synthase 27
TAT 26
cytochrome oxidase 26
transglutaminase 26
PKG 25
DNase 25
caspase-10 24
MMP-3 24
thioredoxin reductase 24
caspase-10 24
thymidylate synthase 23
thrombin 23
cholinesterase 22
MEKK1 22
choline acetyltransferase 21
HSD 20
DNA ligase 19
guanylate cyclase 19
DNA ligase 19
peroxiredoxin 19
gamma-glutamyl transpeptidase 18
matrix metalloproteinase 9 18
farnesyltransferase 18
farnesyltransferase 18
thymidine kinase 17
lipoxygenase 17
matrix metalloproteinase 2 17
citrate synthase 17
SPC 16
glyceraldehyde-3-phosphate dehydrogenase 16
HK2 16
aldehyde dehydrogenase 16
DNA polymerase 15
acid phosphatase 15
CAD 14
CAD 14
glutamine synthetase 14
CAD 14
enolase 14
ACE 13
neutral sphingomyelinase 13
glyceraldehyde-3-phosphate dehydrogenase 13
lysozyme 13
ECH 13
CD13 13
sphingosine kinase 13
15-lipoxygenase 13
ribonucleotide reductase 13
glyceraldehyde-3-phosphate dehydrogenase 13
DCF 13
glyceraldehyde-3-phosphate dehydrogenase 13
glucose-6-phosphate dehydrogenase 12
aldehyde dehydrogenase 12
aldehyde dehydrogenase 12
dihydrofolate reductase 12
gamma-glutamylcysteine synthetase 12
tyrosinase 12
mu-calpain 12
diaphorase 12
lipase 12
aldehyde dehydrogenase 12
aldehyde dehydrogenase 12
ribonucleotide reductase 12
aldose reductase 11
aconitase 11
m-calpain 11
CPT 11
myosin light chain kinase 11
more...
Compound
DNA 4861
oxygen 3726
Dec 2464
MTT 1952
boron 1305
TNF 1159
glucose 986
MDA 942
calcium 938
GSH 860
GSH 860
Clin 800
water 745
dUTP 720
nitric oxide 594
iodine 570
bromide 563
ATP 559
cysteine 549
hydrogen 496
sodium 410
ADP-ribose 370
N-acetylcysteine 368
serine 320
H2O2 313
MEK 306
tyrosine 296
glutamate 289
ethanol 252
DDP 240
ADP 230
Curcumin 224
alanine 215
Asp 211
ADP 210
Cyt 210
ADP 210
acetate 204
nitrogen 199
creatinine 196
retinoic acid 194
urea 191
acridine 191
phosphate 185
ADR 174
Adriamycin 172
galactose 172
cAMP 169
CAT 166
CAT 166
CAT 166
threonine 163
zinc 151
Hoechst 33342 150
arginine 137
Neuronal 136
cadmium 131
PEG 126
iron 125
Cytochrome c 124
Panam 118
NH2 117
copper 111
Resveratrol 110
selenium 105
diacetate 104
Melatonin 104
5-FU 104
MPP 103
MPP 103
lysine 101
ethyl acetate 100
potassium 100
Pac 98
Quercetin 95
MPTP 95
AMP 95
THP 93
THP 93
Cardiol 88
leucine 85
MAP 84
methanol 83
anthracene 81
sulfate 80
GSSG 79
methionine 79
NAD 78
salt 77
DMSO 77
H2S 76
PEG 71
MTS 71
VP-16 71
Paclitaxel 70
chalcone 68
ACS 67
ACS 67
manganese 66
TEM 65
aldehyde 64
nicotinamide 61
BCR 61
NAD 61
gallic acid 60
fluorine 60
Hematoxylin 59
Berberine 59
DBA 58
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 57
aldehyde 57
cGMP 56
ATF 55
Ang II 55
8-OHdG 52
glutamine 51
TNM 51
STZ 51
PGE 50
Estrogen 50
Genistein 49
Estrogen 48
Insulin 48
pyrrolidine 47
APAP 47
His 46
kaempferol 46
ALP 45
MDR 44
Emodin 44
NOXA 44
Vimentin 43
aluminum 43
DPPH 43
cobalt 43
NMDA 43
Glutamate 43
naphthoquinone 42
Angiotensin II 42
UTP 42
pyrrolidine 42
H2S 42
CO2 42
silver 42
naphthoquinone 41
pyrimidine 41
naphthoquinone 41
naphthoquinone 41
naphthoquinone 41
naphthoquinone 41
naphthoquinone 41
FK506 41
formaldehyde 40
Luteolin 40
pyrimidine 40
isoquinoline 40
Oridonin 39
ICI 39
Cer 39
homocysteine 39
more...