Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P10415 (
Bcl-2
)
33,771
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Kaposi's Sarcoma
(KS) is an angioproliferative disease that is characterized by proliferation of spindle-shaped cells predominantly of vascular endothelial cell origin, neoangiogenesis, inflammatory cell infiltration, and edema. Although the lesions of classical KS and AIDS-associated KS (AIDS-KS) share common histological features, AIDS-KS occurs at a markedly higher frequency with a more aggressive clinical course. Immunohistochemical analyses of 26 evolutionarily staged AIDS-KS lesions derived from HIV-infected patients demonstrate significant cytoplasmic levels of
Bcl-2
, a protooncogene known to prolong cellular viability and to antagonize apoptosis.
Bcl-2
expression increases as the pathological stage of KS advances. Immunohistochemical analyses of classical KS lesions demonstrate prevalent expression of
Bcl-2
as well, indicating that upregulation of
Bcl-2
may be important in the pathogenesis of both classical and AIDS-associated KS. Coexpression of
Bcl-2
and factor VIII-related antigen in spindle-shaped cells present within KS lesions suggests that
Bcl-2
is upregulated within the vascular endothelial spindle-shaped cells of KS. The consequences of upregulated
Bcl-2
expression within KS lesions may be prolonged spindle cell viability which, when coupled with dysregulated cellular proliferation due in part to synergistic activities of inflammatory and angiogenic cytokines and HIV-1 Tat protein, may result in the maintenance, growth, and progression of KS.
...
PMID:Immunihistochemical detection of Bcl-2 in AIDS-associated and classical Kaposi's sarcoma. 864 47
