Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P10415 (Bcl-2)
 33,771 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The autopsy of a 76-year-old Japanese female patient, which revealed thymic carcinoma with various tumor markers such as NSE, CYFRA, and CA-125, is presented. The patient died from hepatic failure because the liver was overtaken by the tumors. At autopsy, the thymic carcinoma was found to have metastased only in the liver. From microscopical analyses and electron microscopical findings, we diagnosed poorly differenciated squamous cell carcinoma of thymic origin. In the histochemical analyses, the tumor cells were positively stained in CA 125, CA 19-9, EMA, NSE, AE 1, AE 3, CEA, S-100, glimerius and Bcl-2. These date suggest that the tumor cells produced various tumor markers. In 222 autopsy cases of thymic malignant tumor observed in Japan over a period of 4 years, the dominant pathohistological image was squamous cell carcinoma. It is interesting that the greatest number of combined malignant tumors with thymic malignancies were thyroid papillary carcinomas.
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PMID:[An autopsy case of thymic carcinoma producing various tumor markers and the examination of 222 autopsy cases of thymic malignant tumor in Japan]. 1084 55

Intrathyroid thymic carcinoma (ITCA) is a rare neoplasm of the thyroid gland, that is difficult to diagnose because of its complex pathologic and immunohistochemical characteristics. Here, we report two cases that may provide a better understanding of this disease. Case 1 is a 30-year-old man, and Case 2 is a 42-year-old man. The two cases showed an irregular solid thyroid mass on sonography. Histological examination revealed the solid growth of epithelial cells separated by bands of dense, hyalinized, and fibrous stroma. Tumor cells were positive for the expression of CD5, HMWK, CK19, CK5/6, CK7, EMA, CD117, p63, Bcl-2, and NANOG. It is noteworthy that the neuroendocrine markers Syn, NSE, and CgA were also observed. In Case 1, chemotherapy combined with radiotherapy, chest CT showed lung metastasis 4 months after resection. The patient was alive as of postoperative follow up lasting 46 months. Radical operation combined with radiotherapy was performed in case 2, and the patient was alive as of follow-up lasting 42 months.
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PMID:Intrathyroid thymic carcinoma: report of two cases with pathologic and immunohistochemical studies. 3194 93