Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P10145 (IL-8)
 23,849 document(s) hit in 31,850,051 MEDLINE articles (0.02 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
IL-8 23849
IL-6 8897
cytokine 7165
TNF 4070
IL-10 3306
tumor necrosis factor 2664
chemokine 2649
TNF-alpha 2183
lipopolysaccharide 1767
Mol 1566
MCP-1 1536
Sep 1473
IL-4 1464
IL-1 1406
IFN 1336
IL-2 1234
LPS 1178
RANTES 1168
Cytokine 1104
p38 1027
interferon 980
TLR4 941
CXCL10 846
IFN-gamma 835
IL-17 804
CCL2 801
IL-1 beta 776
GM-CSF 775
tumor necrosis factor alpha 727
p65 705
ICAM-1 701
THP 683
VEGF 665
MAPK 650
TLR2 649
vascular endothelial growth factor 645
IL6 625
interleukin-6 607
IL-5 599
CXCL1 588
MIP 588
IL-13 586
CXCR1 542
CXCR2 515
C-reactive protein 491
IL-18 471
ERK1 459
collagen 456
ERK 442
CD4 417
granulocyte 414
JNK 413
interferon-gamma 405
CD14 400
monocyte chemoattractant protein-1 399
gut 381
vascular cell adhesion molecule-1 355
myeloperoxidase 350
COX-2 346
adhesion molecule 345
inducible nitric oxide synthase 344
AP-1 339
MMP-9 339
granulocyte-macrophage colony-stimulating factor 336
interleukin 6 311
G-CSF 305
E-selectin 305
IL-15 298
monocyte chemotactic protein 296
monocyte chemoattractant protein 292
CD11b 288
IL-1 alpha 288
TGF-beta 287
GRO 287
macrophage colony-stimulating factor 272
MIP-1alpha 268
matrix metalloproteinase 268
CXC chemokine 267
CCL20 263
Pseudomonas 260
IL-3 259
IL-7 258
CD8 257
MyD88 251
caspase-3 247
insulin 245
mitogen-activated protein 234
CCL3 232
CSF 231
CD86 226
CXCL5 226
extracellular signal-regulated kinase 225
intercellular adhesion molecule-1 224
CXCL2 223
eotaxin 221
IL1B 220
PI3K 219
CRP 219
mast cell 219
CXCL12 215
CCL4 212
CD40 211
CXCL9 211
superoxide dismutase 208
TLR3 207
RANTES) 207
IL-1ra 205
IL10 205
IgE 204
ROS 202
cyclooxygenase-2 198
fibronectin 196
STAT3 194
albumin 191
MIP-1beta 191
CD18 190
HLA-DR 190
p53 187
IL-23 182
interferon gamma 181
p38 mitogen-activated protein kinase 177
IgA 173
c-Jun 171
AKT 170
lymphoid 168
chemokine receptor 167
granulocyte colony-stimulating factor 165
p50 165
thrombin 161
catalase 161
MMP-2 161
CD80 159
CXCR4 158
IkappaBalpha 156
SOD 154
IL1 150
MMP9 149
cyclooxygenase 148
lactate dehydrogenase 147
lysozyme 147
MMP-1 146
ATP 145
Bcl-2 143
C-C 141
TLR9 141
TLR5 141
PDGF 140
IL-22 135
GSH 133
defensin 130
IL-11 130
leptin 129
adiponectin 128
EGF 127
monocyte chemotactic protein 1 126
neutrophil elastase 123
epidermal growth factor 122
CD83 122
tyrosine kinase 122
mucin 118
more...
Disease
cancer 1887
tumor 1628
asthma 636
MIP 588
sepsis 545
sepsis 504
rheumatoid arthritis 502
chronic obstructive pulmonary disease 481
atherosclerosis 383
breast cancer 355
infectious diseases 348
tumor growth 341
HIV 337
cystic fibrosis 316
virus infection 306
psoriasis 290
tumor progression 289
melanoma 275
carcinoma 272
inflammatory bowel disease 260
arthritis 255
periodontitis 250
osteoarthritis 249
diabetes 246
obesity 245
pneumonia 229
bacterial infection 229
Infection 224
carcinogenesis 202
tumorigenesis 201
ischemia 194
colitis 193
gastric cancer 188
tuberculosis 184
Mycobacterium 184
adenocarcinoma 182
colorectal cancer 181
influenza 172
metastases 167
ulcerative colitis 166
leukemia 159
Crohn's disease 155
mastitis 155
lung cancer 154
lung disease 154
hepatocellular carcinoma 146
plaque 145
immunodeficiency 136
GSH 133
squamous cell carcinoma 132
prostate cancer 131
pertussis 128
cardiovascular disease 128
Blocking 123
gastritis 121
atopic dermatitis 119
depression 114
Alzheimer's disease 114
ovarian cancer 111
skin disease 106
dermatitis 105
CCL 104
hypertension 100
systemic lupus erythematosus 100
colon cancer 97
HGF 97
glioma 96
uterus 95
periodontal disease 94
pancreatic cancer 93
multiple sclerosis 92
SARS 92
type 2 diabetes 92
stroke 91
COPD 91
Chlamydia 89
AIDS 88
tumor angiogenesis 88
cold 86
AGS 85
respiratory disease 84
meningitis 80
MCF 80
cytomegalovirus 78
Helicobacter pylori infection 78
lymphoma 77
glioblastoma 77
Haemophilus 76
allergic rhinitis 74
Mycoplasma 70
autoimmune disease 69
Adhesion 68
adult respiratory distress syndrome 68
SCID 66
endometriosis 66
hepatitis C 65
SEM 65
acne 63
acute pancreatitis 62
bronchiolitis 62
myocardial infarction 61
dengue 61
chorioamnionitis 60
pulmonary edema 59
preeclampsia 59
malaria 58
PAF 58
non-small cell lung cancer 57
SDS 57
acute myeloid leukemia 57
vasculitis 56
endometritis 55
RSV infection 55
PHA 54
eosinophilia 53
astrocytoma 53
coronary artery disease 53
metabolic syndrome 52
infertility 52
multiple myeloma 51
NOD 50
Epstein 50
synovitis 50
cirrhosis 50
aggressiveness 49
osteosarcoma 48
bladder cancer 48
liver disease 48
urinary tract infection 47
myocardial ischemia 47
heart failure 46
hyperglycemia 45
emphysema 45
peritonitis 45
necrotizing enterocolitis 45
chronic hepatitis 45
cornea 45
enteritis 44
schizophrenia 44
uveitis 44
lung carcinoma 44
primary tumor 44
hepatitis 44
Melanoma 44
idiopathic pulmonary fibrosis 44
epithelial ovarian cancer 44
Shiga 43
neutropenia 43
irritable bowel syndrome 43
Klebsiella 43
renal disease 42
hepatitis B 42
encephalitis 41
lupus 41
glomerulonephritis 40
cognitive impairment 40
osteoporosis 40
pancreatitis 40
neuroblastoma 40
renal cell carcinoma 39
more...
Symptom
pain 179
diarrhea 167
respiratory distress 153
anesthesia 68
fatigue 52
overweight 46
cough 36
erythema 34
cachexia 30
hyperoxia 29
dyspnea 27
hypothermia 24
seizures 24
headache 23
arthralgia 21
exhaustion 21
angina 20
wheezing 17
collapse 17
dry eye 17
anorexia 17
vomiting 16
skin irritation 16
discomfort 13
discomfort 13
splenomegaly 12
starvation 12
chills 12
abdominal pain 12
low back pain 11
pelvic pain 10
skin damage 10
acidity 9
nasal discharge 9
acute stress 9
nausea 9
myalgia 9
sleepiness 8
analgesia 8
back pain 7
flushing 7
weakness 7
HSA 7
Scratch 6
sneezing 6
chronic cough 6
Ill 6
hypercapnia 5
microbial colonization 5
constipation 5
fever of unknown origin 5
lethargy 5
twitching 4
hepatosplenomegaly 4
functional recovery 4
spasm 4
thinning 4
agitation 4
rhinorrhea 4
ataxia 4
bone pain 4
tremor 4
tachypnea 4
sciatica 3
Ear swelling 3
colic 3
chest pain 3
sore throat 3
insomnia 3
rigors 3
hot flashes 3
skin irritant 3
intestinal bleeding 3
paresis 3
decreased appetite 3
nasal congestion 3
Wind 3
hepatomegaly 2
itchy nose 2
Respiratory symptoms 2
Organ failure 2
limb pain 2
acute abdomen 2
Welt 2
Depressive symptoms 2
labored breathing 2
regurgitation 2
bladder pain 2
dystonia 2
nausea and vomiting 2
stridor 2
acute pain 2
exertional angina 2
Hudson 2
bloating 2
myoclonus 2
nerve pain 1
heartburn 1
hemoptysis 1
Severe pain 1
chest tightness 1
hoarseness 1
rales 1
hunger 1
numbness 1
partial seizure 1
hyperemesis gravidarum 1
hypoproteinemia 1
Sedation 1
distraction 1
urinary frequency 1
ACHE 1
abdominal discomfort 1
ENT 1
cerebellar ataxia 1
Beau's lines 1
sinus headache 1
chorea 1
stomach pain 1
UTI symptoms 1
shortness of breath 1
catarrh 1
Gastrointestinal symptoms 1
chronic back pain 1
physical appearance 1
Lung hyperinflation 1
spasticity 1
persistent cough 1
nipple discharge 1
ophthalmoplegia 1
tenesmus 1
snoring 1
athetosis 1
nipple discharge 1
Postoperative pain 1
drooling 1
exertional dyspnea 1
Stiffness 1
loss of taste 1
sinus pain 1
localized edema 1
Acute urinary retention 1
bitter taste 1
emaciation 1
syncope 1
Involuntary Movement 1
blurred vision 1
Anoxia 1
Spots 1
knee pain 1
breakthrough pain 1
Mills 1
postnasal drip 1
disturbed balance 1
hypotonia 1
halitosis 1
neuralgia 1
Neuropathic pain 1
acute abdominal pain 1
hypersomnia 1
more...
Drug
IL-2 1236
CSF 928
IFN-gamma 822
Dermatol 380
G-CSF 295
IL-1ra 226
ROS 202
IL-11 129
CCL 104
MAP 96
lysine 84
Asthma 79
IFN-beta 64
Bifidobacterium 55
Monit 42
Histamine 42
Cardiovasc 40
ROC 36
p75 34
ascorbate 29
vitamin E 27
Dial 25
uPA 25
ZnO 24
CAM 23
Albumin 20
Lovastatin 19
Budesonide 19
TAK 19
Ethanol 19
MRC 18
Leaf 18
Gel 17
TiO2 16
ampicillin 14
Simvastatin 13
CTX 13
EPA 13
GEO 13
ICI 13
Imiquimod 13
Heme 12
TTC 12
ABC 12
lactose 12
Nephron 12
Indomethacin 12
Azithromycin 11
Asn 10
Kenyan 10
Activin 10
KGF 10
NAG 9
Infliximab 9
Infliximab 9
ALA 9
niacin 8
ADM 8
CoCl2 8
NBT 8
CTX 8
CoCl2 8
Vitamin E 8
CTX 8
Silica 8
Nephron 8
Glycyrrhiza 8
Ulinastatin 7
Rebamipide 7
Theophylline 7
balanced salt solution 7
Anakinra 7
Tocilizumab 7
PTH 7
Allergen 7
Aprotinin 7
Biopolymers 7
Fluticasone propionate 7
Angiotensin II 6
Mutagen 6
Sorafenib 6
TAT 6
TAC 6
Fraction 6
Omalizumab 6
Nitric Oxide 6
Spectrum 6
Ginseng 6
EE2 6
ENT 6
caffeine 6
Survanta 6
Gefitinib 5
Prednisolone 5
Tacrolimus 5
Amiloride 5
CaCl2 5
CaCl2 5
CaCl2 5
Glutathione 5
MDM 5
DNase I 5
nitroglycerin 5
Rifaximin 5
Meth 5
Propofol 5
CFS 5
Adriamycin 5
Retinoic acid 5
Amiloride 5
PTC 5
Doxycycline 5
Emodin 5
Bevacizumab 5
Emodin 5
SiO2 5
BCG vaccine 4
Lenalidomide 4
ETS 4
Gelatin 4
NADH 4
CIA 4
Salbutamol 4
Taxol 4
Myricetin 4
ID2 4
Rituximab 4
Forskolin 4
Moxifloxacin 4
ETA 4
Sivelestat 4
Ringer's solution 4
DEX 4
Imatinib 4
1,8-Cineole 4
Zoledronic acid 4
Docetaxel 4
Fluorescein 3
Rolipram 3
Menthol 3
Calcipotriol 3
Misoprostol 3
Cetuximab 3
Filgrastim 3
Irsogladine maleate 3
PDL 3
G418 3
Sodium nitroprusside 3
Bortezomib 3
Parkin 3
citric acid 3
Zileuton 3
BLM 3
Aloe 3
Filgrastim 3
CPT-11 3
MOF 3
Rosiglitazone 3
Glucagon 3
Talc 3
more...
Enzyme
mitogen-activated protein kinase 1763
ERK 697
MIP 589
peroxidase 384
superoxide dismutase 314
luciferase 293
protein kinase 253
protein kinase C 243
collagenase 240
catalase 215
reverse transcriptase 201
focal adhesion kinase 191
caspase-3 182
IKK 177
MEK 167
elastase 165
thrombin 155
lactate dehydrogenase 154
lysozyme 150
neutrophil elastase 149
trypsin 129
glutathione peroxidase 113
MMP-3 111
alkaline phosphatase 99
proteasome 98
caspase-1 93
NADPH oxidase 93
NADPH oxidase 89
MAP 81
alanine aminotransferase 80
phospholipase C 80
aspartate aminotransferase 79
tryptase 76
phosphatidylinositol 3-kinase 74
RNA polymerase 73
phospholipase A2 58
acid phosphatase 58
creatine kinase 56
APC 56
NO synthase 56
MMP 56
urokinase-type plasminogen activator 55
glutathione S-transferase 50
phosphodiesterase 47
RNase 47
RNase 47
ATPase 47
calcineurin 47
matrix metalloproteinase 9 47
PARP 45
transcriptase 44
caspase-8 42
AMP-activated protein kinase 42
phosphoinositide 3-kinase 40
glutathione reductase 40
heme oxygenase 40
BAL 36
NQO1 34
caspase-9 34
glyceraldehyde-3-phosphate dehydrogenase 33
urease 32
AMPK 31
granzyme B 29
urease 29
GSK 28
AMPK 26
myosin light chain kinase 26
lipoxygenase 26
AST 25
ECH 25
NOS 25
tissue plasminogen activator 24
arginase 23
CD13 23
histone acetyltransferase 22
TSP-1 22
hyaluronidase 21
beta-galactosidase 21
neuraminidase 20
matrix metalloproteinase 2 20
thromboplastin 19
ACE 19
glyceraldehyde-3-phosphate dehydrogenase 19
ACS 18
interstitial collagenase 17
lipase 17
plasmin 17
hyaluronidase 16
xanthine oxidase 15
beta-glucuronidase 15
MEKK1 15
indoleamine 2,3-dioxygenase 15
CD10 15
ceruloplasmin 15
CYP3A4 15
TACE 14
proteinase K 14
renin 13
phospholipase D 13
hexosaminidase 13
glyceraldehyde-3-phosphate dehydrogenase 13
ribonuclease 13
ribonuclease 13
glyceraldehyde-3-phosphate dehydrogenase 13
pepsin 13
glyceraldehyde-3-phosphate dehydrogenase 13
cathepsin G 12
gamma-glutamyl transpeptidase 12
aldehyde dehydrogenase 12
P-glycoprotein 11
chymase 11
PAM 11
adenylate cyclase 11
TOR 11
PAH 10
Der p 1 10
proteinase-3 10
AGT 10
protein phosphatase 2A 10
kallikrein 10
apyrase 10
papain 10
GAS 10
adenosine deaminase 9
MDP 9
chitinase 9
cathepsin B 9
prolyl hydroxylase 9
prostate-specific antigen 9
adenosine deaminase 9
thyroid peroxidase 9
p100 9
DCF 9
DNA polymerase 8
aldehyde dehydrogenase 8
hormone-sensitive lipase 8
aldehyde dehydrogenase 8
cdc2 8
thioredoxin reductase 8
diamine oxidase 8
guanylate cyclase 8
aldehyde dehydrogenase 8
GRK5 8
aldehyde dehydrogenase 8
enolase 8
peroxiredoxin 7
chondroitinase 7
topoisomerase 7
caspase-7 7
DNase 7
chloramphenicol acetyltransferase 7
PKG 7
neutrophil collagenase 7
p80 7
DNA methyltransferase 7
lipoprotein lipase 7
sialidase 7
caspase-7 7
sulfatase 6
acetylcholinesterase 6
more...
Compound
TNF 4070
Dec 1606
DNA 1260
Clin 1107
oxygen 1055
THP 683
THP 683
calcium 639
nitric oxide 393
acetate 364
glucose 361
water 317
sodium 304
sulfate 218
cysteine 214
tyrosine 208
PGE2 194
MTT 186
PMA 186
MDA 182
Phe 182
PMA 178
PGE 176
arginine 175
serine 161
cAMP 158
hydrogen 155
leucine 149
phosphate 148
ATP 146
GSH 137
GSH 137
ethanol 128
iron 123
lysine 115
zinc 114
nitrogen 102
galactose 100
creatinine 96
H2O2 93
vitamin D 92
MEK 91
methionine 89
MAP 86
NH2 86
FMLP 84
Dexamethasone 80
urea 79
N-acetylcysteine 76
alanine 70
CAT 63
CAT 62
CAT 62
SDS 61
nickel 61
hyaluronic acid 58
bromide 58
retinoic acid 58
CO2 57
titanium 57
threonine 55
Curcumin 55
salt 54
copper 50
AMP 49
Cardiol 49
silver 49
pyrrolidine 48
iodine 48
PEG 47
His 46
pyrrolidine 45
ASA 45
neopterin 45
Resveratrol 44
nitrate 43
Histamine 42
glutamine 42
tryptophan 41
PAM 41
potassium 40
ADP 40
Thrombin 38
palmitic acid 38
ADP 37
aldehyde 37
Tumor Necrosis Factor 37
ADP 37
BAL 36
glycerol 36
tryptophan 36
phenol 35
DMSO 35
nicotinamide 34
methanol 34
tryptophan 34
NADPH 34
tryptophan 34
NADPH 34
Vitamin D 33
EDTA 33
cobalt 33
EDTA 33
formaldehyde 32
Asp 32
glutamate 31
Cortisol 31
selenium 31
CAM 31
diacetate 31
BCG 30
COS 30
Lactate 29
Gly 29
GTP 29
PEG 29
Poly I 27
FK506 27
DSS 26
dUTP 26
aldehyde 26
butyric acid 26
Collagen 25
Dial 25
MCP 25
fMet 25
Poly(I:C) 25
TEM 24
cGMP 24
Diazepam 24
cadmium 24
proline 24
MTS 24
homocysteine 24
acetic acid 23
Insulin 23
ethyl acetate 23
DHA 23
NAD 23
GSSG 22
Panam 22
prostacyclin 22
kaempferol 22
pyrene 22
ALP 22
Quercetin 22
ammonia 21
formaldehyde 21
DAP 21
Methotrexate 21
NAD 21
H2S 21
uridine 21
DAP 21
Substance P 20
ACS 20
palmitic acid 20
ammonium 20
silicon 20
manganese 19
more...