Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P10145 (
IL-8
)
23,849
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
To understand how neutrophils are recruited to the lung in pneumococcal pneumonia, the ability of pneumococcal components to elicit the chemokine interleukin (IL)-8 from monolayers of cultured human type II cells was assessed. Heat-killed clinical and laboratory strains of Streptococcus pneumoniae and secreted proteins from exponentially growing pneumococci elicited significant quantities of
IL-8
from A549 cells. All strains that elicited
IL-8
production secreted a protein ( approximately 90 kDa) that comigrated on SDS-PAGE with a
C3-binding protein
previously identified in S. pneumoniae. As little as 7 pmol of the purified 90-kDa protein readily elicited levels of
IL-8
production equivalent to those obtained with 1 U of IL-1alpha. Supernatant proteins and heat-killed cells of an isogenic mutant that failed to produce the
C3-binding protein
elicited significantly less
IL-8
than did supernatant proteins or heat-killed cells of the parent strain. These results implicate the
C3-binding protein
of S. pneumoniae in a novel pathway of pulmonary inflammation.
...
PMID:A pneumococcal protein that elicits interleukin-8 from pulmonary epithelial cells. 1076 64
