Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P10145 (
IL-8
)
23,849
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Background:
Nrg4 expression has been linked to brown adipose tissue activity and browning of white adipocytes in mice. Here, we aimed to investigate whether these observations could be translated to humans by investigating
NRG4
mRNA and markers of brown/beige adipocytes in human visceral (VAT) and subcutaneous adipose tissue (SAT). We also studied the possible association of
NRG4
with insulin action.
Methods:
SAT and VAT
NRG4
and markers of brown/beige (
UCP1, UCP3, and
TMEM26
)-related gene expression were analyzed in two independent cohorts (
n
= 331 and
n
= 59). Insulin resistance/sensitivity was measured using HOMA
IR
and glucose infusion rate during euglycemic hyperinsulinemic clamp.
Results:
In both cohort 1 and cohort 2,
NRG4
and thermogenic/beige-related gene expression were significantly increased in VAT compared to SAT. Adipogenic-related genes followed an opposite pattern. In cohort 1, VAT
NRG4
gene expression was positively correlated with BMI and expression of
UCP1, UCP3,
TMEM26
, and negatively with adipogenic (
FASN, PPARG
, and
SLC2A4
)- and inflammatory (
IL6 and
IL8
)-related genes. In SAT,
NRG4
gene expression was negatively correlated with HOMA
IR
and positively with
UCP1
and
TMEM26
gene expression. Multiple linear regression analysis revealed that expression of
TMEM26
gene was the best predictor of
NRG4
gene expression in both VAT and SAT. Specifically,
NRG4
and
TMEM26
gene expression was significantly increased in VAT, but not in SAT stromal vascular fraction cells (
p
< 0.001). In cohort 2, the significant association between
NRG4
and
TMEM26
gene expression in both VAT and SAT was confirmed, and SAT
NRG4
gene expression also was positively correlated with insulin action and the expression of
UCP1
.
Conclusion:
Current findings suggest
NRG4
gene expression as a novel marker of beige adipocytes in human adipose tissue.
...
PMID:Neuregulin 4 Is a Novel Marker of Beige Adipocyte Precursor Cells in Human Adipose Tissue. 3076 90
