Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P10145 (
IL-8
)
23,849
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Interactions between
interleukin 8
(
IL-8
) and endothelial cells play an important role in the emigration of mononuclear cells from the blood into areas of inflammation. We examined the ability of specific second-line antirheumatic drugs to regulate (
IL-8
) gene expression and protein secretion in interleukin 1 (IL-1) stimulated human umbilical vein endothelial cells and peripheral blood mononuclear cells. The drugs sodium aurothiomalate, D-penicillamine and sulphasalazine were all able to modulate
IL-8
mRNA synthesis in and protein secretion from endothelial cells. A bimodal effect was observed: at low concentrations
IL-8
was suppressed, whereas higher concentrations resulted in an increased
IL-8
production. In endothelial cells, treatment with hydrocortisone led to a linear suppression of
IL-8
production in concentrations ranging from 0.5 micrograms/ml up to 500 micrograms/ml.
Sulphapyridine
, auranofin, hydroxychloroquine and methotrexate, had no effect on
IL-8
secretion in endothelial cells. By contrast, 5-aminosalicylic acid induced a threefold increase in the
IL-8
release. In peripheral blood mononuclear cells it was only possible to suppress the
IL-8
production by hydrocortisone treatment. These results indicate that suppression of
IL-8
production in endothelial cells could be an important factor in the mode of action for a number of second-line antirheumatic drugs.
...
PMID:The effect of second-line antirheumatic drugs on interleukin-8 mRNA synthesis and protein secretion in human endothelial cells. 135 40
