Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
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Target Concepts:
Gene/Protein
Disease
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Enzyme
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Query: UNIPROT:P10145 (
IL-8
)
23,849
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A delayed-type hypersensitivity (DTH) response to a dermatophyte antigen is one of the host defense mechanisms. Peripheral blood mononuclear cells from patients with dermatophytosis produce a high level of IFN-gamma in response to stimulation with
trichophytin
. The presence of IFN-gamma mRNA in skin lesions of dermatophytosis was detected using reverse transcription-polymerase chain reaction. IFN-gamma-positive cells were observed immunohistochemically in the upper dermis of the skin lesions. These findings support the hypothesis that the skin lesions of dermatophytosis are associated with a Th1 response. The Th1 response, which is characterized by IFN-gamma release, is thought to be involved in the host defense against dermatophytes and to reflect cutaneous reaction in dermatophytosis. The stimulation of
trichophytin
significantly enhanced the release of
IL-8
from keratinocytes. These findings account for the accumulation of neutrophils beneath the stratum corneum. The capacity of
trichophytin
-stimulated keratinocytes to release an enhanced level of
IL-8
thus suggests that these cells can indeed help to induce the acute inflammatory response seen in dermatophyte infection. It therefore appears that keratinocytes not only play an important structural role in the formation of a physical barrier to dermatophytes but may also play an important functional role in initiating cutaneous inflammatory reactions, which might be involved in the host defense against dermatophytes. The production of IFN-gamma by peripheral blood mononuclear cells from patients with tinea unguium in response to stimulation with
trichophytin
was not impaired in contrast to that from patients without tinea unguium. Comparable lymphocyte proliferation with
trichophytin
was observed in both groups. No deficiency in Th1 response to dermatophyte antigen was shown in patients with tinea unguium by measuring the release of IFN-gamma, which plays a role in the effector phase of the DTH reaction. A deficiency of Th1 response to dermatophyte antigen, therefore, does not appear to play an important role in the establishment of tinea unguium.
...
PMID:[Immune response in dermatophytosis]. 1461 93
Dermatophytes reside in the stratum corneum of the epidermis, and one scenario in superficial dermatophytosis is that fungi stimulate keratinocytes to secrete chemokines, thereby attracting inflammatory cells. We investigated the effect of the cytokine / chemokine production of keratinocytes solely stimulated by fungal elements. The fungal elements beta-D-glucan and
trichophytin
from Trichophyton rubrum and Trichophyton mentagrophytes augmented production of
IL-8
and IL-1 alpha of cultured normal human epidermal keratinocytes. It was found that keratinocytes can recognize elements of dermatophytes as a pathogen. Next we examined the effect of liranaftate, a representative Japanese thiocarbamate antifungal agent, on the production of
IL-8
and IL-1 alpha. Keratinocytes were incubated with this antifungal drug in the presence of beta -glucan or
trichophytin
. Augmented production of
IL-8
was profoundly suppressed by the addition of liranaftate to the culture in a dose-dependent manner. Clinically, liranaftate an antifungal drug with
IL-8
-decreasing activity may reduce infiltration of neutrophils in the skin and their invasion into the epidermis.
...
PMID:[Anti-fungal drug liranaftate suppresses fungal element-promoted production of IL-8 in normal human keratinocytes]. 1900 60
