Gene/Protein
Disease
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Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
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Target Concepts:
Gene/Protein
Disease
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Query: UNIPROT:P10145 (
IL-8
)
23,849
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Proinflammatory cytokines have been identified in herniated intervertebral discs in humans, and such cytokines have experimentally been demonstrated to be important in the pathophysiological mechanisms of disc herniation. Cerebrospinal fluid (CSF) and serum concentrations of interleukin (IL)-1beta IL-6,
IL-8
, interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha were investigated using the enzyme-linked immunosorbent assay (ELISA) technique in 39 patients with lumbar disc herniation and sciatica. Pain duration and pain intensity (visual analogue scale, VAS) were recorded at inclusion, and a clinical examination was performed evaluating neurological findings. The extent of disc herniation (protrusion or extrusion/sequestration) was evaluated perioperatively. Normal concentrations of IL-1beta, IL-6, IFN-gamma and TNF-alpha were present in CSF and serum in almost all patients with lumbar disc herniation. The concentrations of
IL-8
in CSF were increased in 12 out of 39 patients, and these increased levels of
IL-8
correlated to a short duration of pain and to more pronounced herniation (extrusion or sequestration). No relationship between
IL-8
concentrations in CSF and pain intensity, positive neurological findings or a positive straight leg-raising (SLR) test was found. The observation of increased concentrations of
IL-8
in CSF in patients with a short duration of symptoms supports the concept of the initial involvement of inflammatory mechanisms after a disc herniation. The finding that most of the patients with increased concentrations of
IL-8
in CSF had an extrusion or a sequestration may suggest that the increase in
IL-8
is related to mechanical
nerve root compression
, but may also indicate a biochemical effect exerted by the herniated disc on the surrounding tissue. Further studies on the potential role of
IL-8
as a biomarker for disc herniation are warranted.
...
PMID:Proinflammatory cytokines in cerebrospinal fluid and serum in patients with disc herniation and sciatica. 1193 Oct 66
