Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P10145 (
IL-8
)
23,849
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Only scarce data pertaining to
interleukin 8
(
IL-8
) and monocyte chemoattractant protein-1 (MCP-1) chemokines in human aneurysm can be found in the current literature. Therefore, the aim of this study was the evaluation of cerebrospinal fluid (CSF) and serum
IL-8
and MCP-1 concentration in unruptured intracranial aneurysm (UIA) patients (n = 25) compared to the control group (n = 20).
IL-8
and MCP-1 concentrations were measured with ELISA method. We demonstrated that CSF
IL-8
concentration of UIA patients is significantly higher (p < 0.001) than that presented in the serum, which can indicate its local synthesis within central nervous system. CSF
IL-8
concentration was also significantly related to aneurysm size, which may reflect the participation of
IL-8
in the formation and development of brain aneurysms.
IL-8
Quotient (CSF
IL-8
divided by serum
IL-8
) in UIA patients was statistically higher compared to control individuals (p = 0.045). However, the diagnostic utility analysis did not equivocally indicate the diagnostic usefulness of the
IL-8
Quotient evaluation in
brain aneurysm
patients. Nevertheless, this aspect requires further study.
...
PMID:Ratio of IL-8 in CSF versus Serum Is Elevated in Patients with Unruptured Brain Aneurysm. 3251 49
