Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P10145 (
IL-8
)
23,849
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The incidence of melanoma is rising at an alarming rate and we are still awaiting an effective treatment for this malignancy. In its early
stage, melanoma
can be cured by surgical removal, but once metastasis has occurred there is no effective treatment. Recent findings have suggested multiple functional implications of
CXCL8
and its cognate receptors, CXCR1 and CXCR2, in melanoma pathogenesis, thus underscoring their importance as targets for cancer therapy. This review provides an update on the roles of
CXCL8
and its receptors in melanoma progression and metastasis.
...
PMID:CXCL8 and its cognate receptors in melanoma progression and metastasis. 2002 Dec 12
